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Ndufs6 NADH:ubiquinone oxidoreductase core subunit S6 [ Mus musculus (house mouse) ]

Gene ID: 407785, updated on 19-Jun-2024

Summary

Official Symbol
Ndufs6provided by MGI
Official Full Name
NADH:ubiquinone oxidoreductase core subunit S6provided by MGI
Primary source
MGI:MGI:107932
See related
Ensembl:ENSMUSG00000021606 AllianceGenome:MGI:107932
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IP13
Summary
Acts upstream of or within several processes, including mitochondrion organization; multicellular organism aging; and respiratory electron transport chain. Located in mitochondrion. Part of mitochondrial respiratory chain complex I. Is expressed in limb; respiratory system; and skeleton. Used to study mitochondrial complex I deficiency. Human ortholog(s) of this gene implicated in cervical cancer and nuclear type mitochondrial complex I deficiency 9. Orthologous to human NDUFS6 (NADH:ubiquinone oxidoreductase subunit S6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 124.2), placenta adult (RPKM 69.8) and 26 other tissues See more
Orthologs
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Genomic context

See Ndufs6 in Genome Data Viewer
Location:
13 C1; 13 39.69 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (73467995..73476574, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (73319876..73328482, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene Iroquois homeobox 4 Neighboring gene VISTA enhancer mm68 Neighboring gene 40S ribosomal protein S28 pseudogene Neighboring gene STARR-seq mESC enhancer starr_34990 Neighboring gene mitochondrial ribosomal protein L36 Neighboring gene STARR-seq mESC enhancer starr_34991 Neighboring gene ephemeron, early developmental lncRNA

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC107676

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response, signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in aerobic respiration NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within cell growth IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular senescence IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular senescence IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within circulatory system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mesenchymal stem cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within mesenchymal stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mesenchymal stem cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within mesenchymal stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial electron transport, NADH to ubiquinone IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within mitochondrial respiratory chain complex I assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proton motive force-driven mitochondrial ATP synthesis NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of mitochondrial membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within reproductive system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within respiratory electron transport chain IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within stem cell division IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within stem cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in intracellular anatomical structure IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
part_of mitochondrial respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of mitochondrial respiratory chain complex I IDA
Inferred from Direct Assay
more info
PubMed 
part_of mitochondrial respiratory chain complex I ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in respirasome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
Names
CI-13kD-A
NADH dehydrogenase (ubiquinone) Fe-S protein 6
NADH dehydrogenase Fe-S protein 6
NADH-ubiquinone oxidoreductase 13 kDa-A subunit
complex I-13kD-A
NP_001410642.1
NP_001410643.1
NP_001410644.1
NP_001410645.1
NP_001410646.1
NP_035018.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001423713.1NP_001410642.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC154266
  2. NM_001423714.1NP_001410643.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC154266
    UniProtKB/TrEMBL
    A0A1Y7VM38
  3. NM_001423715.1NP_001410644.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC154266
  4. NM_001423716.1NP_001410645.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC154266
  5. NM_001423717.1NP_001410646.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC154266
  6. NM_010888.3NP_035018.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_035018.1

    Status: VALIDATED

    Source sequence(s)
    AC154266
    Consensus CDS
    CCDS26630.1
    UniProtKB/Swiss-Prot
    P52503, Q5M9J7
    UniProtKB/TrEMBL
    A0A1Y7VM38
    Related
    ENSMUSP00000022097.6, ENSMUST00000022097.6
    Conserved Domains (1) summary
    pfam10276
    Location:75111
    zf-CHCC; Zinc-finger domain

RNA

  1. NR_033306.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154266
    Related
    ENSMUST00000147407.2
  2. NR_187109.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154266
  3. NR_187110.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154266
  4. NR_187112.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154266
  5. NR_187113.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154266
  6. NR_187114.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154266

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    73467995..73476574 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)