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FAM19A1 family with sequence similarity 19 member A1, C-C motif chemokine like [ Homo sapiens (human) ]

Gene ID: 407738, updated on 5-Aug-2018

Summary

Official Symbol
FAM19A1provided by HGNC
Official Full Name
family with sequence similarity 19 member A1, C-C motif chemokine likeprovided by HGNC
Primary source
HGNC:HGNC:21587
See related
Ensembl:ENSG00000183662 MIM:617495; Vega:OTTHUMG00000158745
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAFA1; TAFA-1
Summary
This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 6.6) and prostate (RPKM 0.3) See more
Orthologs

Genomic context

See FAM19A1 in Genome Data Viewer
Location:
3p14.1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (67991592..68546056)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (68040734..68594772)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene succinate-CoA ligase GDP-forming beta subunit Neighboring gene uncharacterized LOC105377148 Neighboring gene SUCLG2 antisense RNA 1 (head to head) Neighboring gene FAM19A1 intron homotypic cluster of transcription factor binding sites enhancer Neighboring gene COP9 signalosome subunit 8 pseudogene 2 Neighboring gene uncharacterized LOC107986019 Neighboring gene uncharacterized LOC105377146 Neighboring gene ribosomal protein lateral stalk subunit P0 pseudogene 8 Neighboring gene proteasome 26S subunit, ATPase 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein FAM19A1
Names
chemokine-like protein TAFA-1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252216.1NP_001239145.1  protein FAM19A1 precursor

    See identical proteins and their annotated locations for NP_001239145.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC139766, AY325114, BC025746
    Consensus CDS
    CCDS54606.1
    UniProtKB/Swiss-Prot
    Q7Z5A9
    Conserved Domains (1) summary
    pfam12020
    Location:41128
    TAFA; TAFA family
  2. NM_213609.3NP_998774.2  protein FAM19A1 precursor

    See identical proteins and their annotated locations for NP_998774.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK290446, BC025746, DA484048, DA485098
    Consensus CDS
    CCDS54606.1
    UniProtKB/Swiss-Prot
    Q7Z5A9
    Related
    ENSP00000418575.1, OTTHUMP00000213370, ENST00000478136.5, OTTHUMT00000352004
    Conserved Domains (1) summary
    pfam12020
    Location:41128
    TAFA; TAFA family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    67991592..68546056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006390.1XP_016861879.1  protein FAM19A1 isoform X2

    Conserved Domains (1) summary
    pfam12020
    Location:40127
    TAFA; TAFA family
  2. XM_017006388.1XP_016861877.1  protein FAM19A1 isoform X2

    Conserved Domains (1) summary
    pfam12020
    Location:40127
    TAFA; TAFA family
  3. XM_017006387.2XP_016861876.1  protein FAM19A1 isoform X1

    UniProtKB/Swiss-Prot
    Q7Z5A9
    Conserved Domains (1) summary
    pfam12020
    Location:41128
    TAFA; TAFA family
  4. XM_017006386.1XP_016861875.1  protein FAM19A1 isoform X1

    UniProtKB/Swiss-Prot
    Q7Z5A9
    Related
    ENSP00000417496.1, OTTHUMP00000213371, ENST00000496687.1, OTTHUMT00000352005
    Conserved Domains (1) summary
    pfam12020
    Location:41128
    TAFA; TAFA family
  5. XM_017006389.1XP_016861878.1  protein FAM19A1 isoform X2

    Conserved Domains (1) summary
    pfam12020
    Location:40127
    TAFA; TAFA family
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