asic1b acid-sensing (proton-gated) ion channel 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: asic1bprovided by ZNC
Official Full Name: acid-sensing (proton-gated) ion channel 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040513-1
See related: Ensembl:ENSDARG00000101866 AllianceGenome:ZFIN:ZDB-GENE-040513-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ASIC1; accn2a; ASIC1-B; zASIC1.1
Summary: Enables ligand-gated sodium channel activity. Predicted to be involved in cellular response to pH; protein homotrimerization; and sodium ion transmembrane transport. Predicted to act upstream of or within sodium ion transport. Is integral component of plasma membrane. Is expressed in gill and integument. Orthologous to human ASIC1 (acid sensing ion channel subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (7042822..7401401, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (7012976..7371543, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The 6 zasic genes studied are broadly expressed in the central nervous system, whereas expression in the peripheral nervous system is scarce. zASICs are activated by extracellular H(+), Na(+) selectivity and blocked by amiloride.
Title: A family of acid-sensing ion channels from the zebrafish: widespread expression in the central nervous system suggests a conserved role in neuronal communication.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ligand-gated sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligand-gated sodium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables ligand-gated sodium channel activity	IEA Inferred from Electronic Annotation more info
enables pH-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables pH-gated monoatomic ion channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables sodium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to pH	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in protein homotrimerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sodium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sodium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: acid-sensing ion channel 1B

Names: acid-sensing ion channel 1; acid-sensing ion channel 1.1; acid-sensing ion channel 1.1-B; amiloride-sensitive cation channel 2 a; amiloride-sensitive cation channel 2-A, neuronal; amiloride-sensitive cation channel 2-A, neuronal-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214791.1 → NP_999956.1 acid-sensing ion channel 1B

See identical proteins and their annotated locations for NP_999956.1

Status: PROVISIONAL

Source sequence(s)

AJ609615

UniProtKB/Swiss-Prot

Q708S8

UniProtKB/TrEMBL

B3DGD8

Related

ENSDARP00000133845.1, ENSDART00000165549.3

Conserved Domains (1) summary

cl02990
Location:66 → 548

ASC; Amiloride-sensitive sodium channel

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007133.7 Reference GRCz11 Primary Assembly

Range

7042822..7401401 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005161667.4 → XP_005161724.1 acid-sensing ion channel 1B isoform X2

UniProtKB/TrEMBL

A0A8M2B8J9

Conserved Domains (1) summary

cl02990
Location:22 → 514

ASC; Amiloride-sensitive sodium channel
XM_005161666.4 → XP_005161723.1 acid-sensing ion channel 1B isoform X1

UniProtKB/TrEMBL

A0A0R4ID46, A0A8M2B8G7

Related

ENSDARP00000132694.1, ENSDART00000171359.2

Conserved Domains (1) summary

cl02990
Location:15 → 528

ASC; Amiloride-sensitive sodium channel