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asic2 acid-sensing (proton-gated) ion channel 2 [ Danio rerio (zebrafish) ]

Gene ID: 407669, updated on 19-May-2025
Official Symbol
asic2provided by ZNC
Official Full Name
acid-sensing (proton-gated) ion channel 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040513-4
See related
Ensembl:ENSDARG00000006849 AllianceGenome:ZFIN:ZDB-GENE-040513-4
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
accn1; zASIC2
Summary
Predicted to enable pH-gated sodium channel activity. Acts upstream of or within response to steroid hormone. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; eye; gill; olfactory rosette; and ovary. Orthologous to human ASIC2 (acid sensing ion channel subunit 2). [provided by Alliance of Genome Resources, May 2025]
Orthologs
human mouse all
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See asic2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 3 NC_133178.1 (36685752..37500119)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 3 NC_007114.7 (37816068..38628549)

Chromosome 3 - NC_133178.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD35 Neighboring gene ribosomal protein S11 Neighboring gene homologous recombination factor with OB-fold Neighboring gene uncharacterized LOC141381357 Neighboring gene uncharacterized LOC110439297 Neighboring gene uncharacterized LOC141381249 Neighboring gene uncharacterized LOC137490685 Neighboring gene uncharacterized LOC137490687 Neighboring gene uncharacterized LOC137490133 Neighboring gene uncharacterized LOC137490689 Neighboring gene uncharacterized LOC103910295 Neighboring gene uncharacterized LOC137490693 Neighboring gene MAGUK p55 scaffold protein 3a

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Acid-sensing ion channel 2 (ASIC2) is selectively localized in the cilia of the non-sensory olfactory epithelium of adult zebrafish. Viña E, et al. Histochem Cell Biol, 2015 Jan. PMID 25161120
  2. Acid-sensing ion channel 2 (ASIC2) in the intestine of adult zebrafish. Levanti MB, et al. Neurosci Lett, 2011 Apr 20. PMID 21356277
  3. Acid-sensing ion channels (ASICs) 2 and 4.2 are expressed in the retina of the adult zebrafish. Viña E, et al. Cell Tissue Res, 2015 May. PMID 25585988
  4. The role of acid-sensing ion channels in epithelial Na+ uptake in adult zebrafish (Danio rerio). Dymowska AK, et al. J Exp Biol, 2015 Apr 15. PMID 25722005
  5. Acid-sensing ion channels are involved in epithelial Na+ uptake in the rainbow trout Oncorhynchus mykiss. Dymowska AK, et al. Am J Physiol Cell Physiol, 2014 Aug 1. PMID 24898589, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results are the first demonstration that ASIC2 and ASIC4 are expressed in the adult zebrafish retina
    Title: Acid-sensing ion channels (ASICs) 2 and 4.2 are expressed in the retina of the adult zebrafish.
  2. The ASIC2 expression in this location might be related to detection of aquatic environment pH variations or to detection of water movement through the nasal cavity.
    Title: Acid-sensing ion channel 2 (ASIC2) is selectively localized in the cilia of the non-sensory olfactory epithelium of adult zebrafish.
  3. The 6 zasic genes studied are broadly expressed in the central nervous system, whereas expression in the peripheral nervous system is scarce. zASICs are activated by extracellular H(+), Na(+) selectivity and blocked by amiloride.
    Title: A family of acid-sensing ion channels from the zebrafish: widespread expression in the central nervous system suggests a conserved role in neuronal communication.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ligand-gated sodium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ligand-gated sodium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables pH-gated sodium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables sodium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to steroid hormone IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
acid-sensing ion channel 2
Names
amiloride-sensitive cation channel 1, neuronal

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214788.1 → NP_999953.1  acid-sensing ion channel 2

    See identical proteins and their annotated locations for NP_999953.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ609618
    UniProtKB/Swiss-Prot
    Q708S5
    UniProtKB/TrEMBL
    B3DFR3
    Related
    ENSDARP00000122509.2, ENSDART00000137038.4
    Conserved Domains (1) summary
    cl02990
    Location:30 → 507
    ASC; Amiloride-sensitive sodium channel

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133178.1 Reference GRCz12tu Primary Assembly

    Range
    36685752..37500119
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068216458.2 → XP_068072559.1  acid-sensing ion channel 2 isoform X2

    UniProtKB/Swiss-Prot
    Q708S5
    UniProtKB/TrEMBL
    B3DFR3

  2. XM_073938667.1 → XP_073794768.1  acid-sensing ion channel 2 isoform X2

  3. XM_073938693.1 → XP_073794794.1  acid-sensing ion channel 2 isoform X7

  4. XM_073938698.1 → XP_073794799.1  acid-sensing ion channel 2 isoform X7

  5. XM_073938695.1 → XP_073794796.1  acid-sensing ion channel 2 isoform X7

  6. XM_073938689.1 → XP_073794790.1  acid-sensing ion channel 2 isoform X6

  7. XM_005164122.6 → XP_005164179.1  acid-sensing ion channel 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BBL3
    Conserved Domains (1) summary
    cl02990
    Location:71 → 538
    ASC; Amiloride-sensitive sodium channel

  8. XM_073938671.1 → XP_073794772.1  acid-sensing ion channel 2 isoform X3

  9. XM_073938687.1 → XP_073794788.1  acid-sensing ion channel 2 isoform X6

  10. XM_073938680.1 → XP_073794781.1  acid-sensing ion channel 2 isoform X5

  11. XM_073938684.1 → XP_073794785.1  acid-sensing ion channel 2 isoform X6

  12. XM_073938677.1 → XP_073794778.1  acid-sensing ion channel 2 isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q708S5.1 GenPept UniProtKB/Swiss-Prot:Q708S5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.