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rbfox1l RNA binding fox-1 homolog 1, like [ Danio rerio (zebrafish) ]

Gene ID: 407613, updated on 9-Sep-2025
Official Symbol
rbfox1lprovided by ZNC
Official Full Name
RNA binding fox-1 homolog 1, likeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040923-2
See related
Ensembl:ENSDARG00000021184 AllianceGenome:ZFIN:ZDB-GENE-040923-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Fox-1; fox1l; a2bp1l; zeh0082; hm:zeh0082
Summary
Enables RNA binding activity. Acts upstream of or within several processes, including RNA splicing; regulation of RNA splicing; and striated muscle cell development. Located in nucleus. Is expressed in several structures, including cardiovascular system; fin bud; musculature system; paraxial mesoderm; and skeletal muscle satellite cell. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See rbfox1l in Genome Data Viewer
Location:
chromosome: 16
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 16 NC_133191.1 (35093182..35112641, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 16 NC_007127.7 (31900131..31919281, complement)

Chromosome 16 - NC_133191.1Genomic Context describing neighboring genes Neighboring gene myeloid leukemia factor 2 Neighboring gene atrophin 1 Neighboring gene uncharacterized LOC110437989 Neighboring gene RAP1 GTPase activating protein-like Neighboring gene uncharacterized LOC108179621 Neighboring gene ribosomal protein S9 Neighboring gene polyhomeotic homolog 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. In vivo assessment of contractile strength distinguishes differential gene function in skeletal muscle of zebrafish larvae. Martin BL, et al. J Appl Physiol (1985), 2015 Oct 1. PMID 26251513, Free PMC Article
  2. A vertebrate RNA-binding protein Fox-1 regulates tissue-specific splicing via the pentanucleotide GCAUG. Jin Y, et al. EMBO J, 2003 Feb 17. PMID 12574126, Free PMC Article
  3. Satellite-like cells contribute to pax7-dependent skeletal muscle repair in adult zebrafish. Berberoglu MA, et al. Dev Biol, 2017 Apr 15. PMID 28279710, Free PMC Article
  4. Pleiotropic contribution of rbfox1 to psychiatric and neurodevelopmental phenotypes in two zebrafish models. Antón-Galindo E, et al. Transl Psychiatry, 2024 Feb 19. PMID 38374212, Free PMC Article
  5. RBFox1-mediated RNA splicing regulates cardiac hypertrophy and heart failure. Gao C, et al. J Clin Invest, 2016 Jan. PMID 26619120, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that Rbfox1l and Rbfox2 have unique and redundant roles in splicing regulation.
    Title: Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cardiac muscle cell development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within heart process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of RNA splicing IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of RNA splicing IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of RNA splicing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within skeletal muscle fiber development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
RNA binding protein fox-1 homolog 1-like
Names
RNA-binding protein
ZFmu1A11s
ataxin 2-binding protein 1-like
fox-1 homolog-like protein 1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214775.1 → NP_999940.1  RNA binding protein fox-1 homolog 1-like

    See identical proteins and their annotated locations for NP_999940.1

    Status: PROVISIONAL

    Source sequence(s)
    AB074763
    UniProtKB/Swiss-Prot
    Q7ZT82
    UniProtKB/TrEMBL
    B3DK66
    Related
    ENSDARP00000016637.7, ENSDART00000027364.8
    Conserved Domains (3) summary
    COG0724
    Location:143 → 237
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12407
    Location:147 → 222
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:257 → 353
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133191.1 Reference GRCz12tu Primary Assembly

    Range
    35093182..35112641 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073924861.1 → XP_073780962.1  RNA binding protein fox-1 homolog 1-like isoform X2

  2. XM_073924860.1 → XP_073780961.1  RNA binding protein fox-1 homolog 1-like isoform X2

  3. XM_005158173.5 → XP_005158230.1  RNA binding protein fox-1 homolog 1-like isoform X1

    UniProtKB/TrEMBL
    A0A8M2B4J5
    Conserved Domains (3) summary
    COG0724
    Location:131 → 225
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12407
    Location:135 → 210
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:245 → 341
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  4. XM_073924863.1 → XP_073780964.1  RNA binding protein fox-1 homolog 1-like isoform X2

  5. XM_073924862.1 → XP_073780963.1  RNA binding protein fox-1 homolog 1-like isoform X2

RNA

  1. XR_012391403.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7ZT82.1 GenPept UniProtKB/Swiss-Prot:Q7ZT82

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