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CAPRIN1 cell cycle associated protein 1 [ Homo sapiens (human) ]

Gene ID: 4076, updated on 10-Dec-2024

Summary

Official Symbol
CAPRIN1provided by HGNC
Official Full Name
cell cycle associated protein 1provided by HGNC
Primary source
HGNC:HGNC:6743
See related
Ensembl:ENSG00000135387 MIM:601178; AllianceGenome:HGNC:6743
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
M11S1; GPIAP1; RNG105; CONDCAC; GPIP137; GRIP137; NEDLAAD; p137GPI
Summary
Enables several functions, including ATP binding activity; molecular condensate scaffold activity; and signaling adaptor activity. Involved in non-membrane-bounded organelle assembly; positive regulation of stress granule assembly; and regulation of gene expression. Located in cell leading edge and cytosol. Is active in intracellular non-membrane-bounded organelle. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in testis (RPKM 43.8), brain (RPKM 23.0) and 25 other tissues See more
Orthologs
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Genomic context

See CAPRIN1 in Genome Data Viewer
Location:
11p13
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (34051731..34102610)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (34188759..34239614)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (34073278..34124157)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4587 Neighboring gene uncharacterized LOC105376621 Neighboring gene uncharacterized LOC124902659 Neighboring gene Sharpr-MPRA regulatory region 4704 Neighboring gene CRISPRi-validated cis-regulatory element chr11.1732 Neighboring gene CRISPRi-validated cis-regulatory element chr11.1733 Neighboring gene CRISPRi-validated cis-regulatory element chr11.1734 Neighboring gene VISTA enhancer hs1858 Neighboring gene Sharpr-MPRA regulatory region 12713 Neighboring gene Sharpr-MPRA regulatory region 9356 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:34011296-34011867 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34018010-34018510 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34018511-34019011 Neighboring gene uncharacterized LOC101929918 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:34072933-34073132 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3250 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4588 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4590 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4591 Neighboring gene uncharacterized LOC124902660 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4592 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4593 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34171467-34171996 Neighboring gene N-acetyltransferase 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4595 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4596 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34177103-34177604 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34181310-34181810 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34181811-34182311 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34195130-34196052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34196053-34196973 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4597 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34204513-34205014 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34205015-34205514 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:34208067-34208830 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:34213997-34214182 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:34214651-34215536 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34215704-34216532 Neighboring gene ankyrin repeat and BTB domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4598 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:34226078-34226684 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:34255548-34256072 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:34260669-34261168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34261893-34262392 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:34263557-34264756 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:34264949-34265620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4600 Neighboring gene Sharpr-MPRA regulatory region 14004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34306064-34306564 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34306565-34307065 Neighboring gene MPRA-validated peak1251 silencer Neighboring gene MMADHC pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Neurodegeneration, childhood-onset, with cerebellar ataxia and cognitive decline
MedGen: C5882726 OMIM: 620636 GeneReviews: Not available
not available
Neurodevelopmental disorder with language impairment, autism, and attention deficit-hyperactivity disorder
MedGen: C5935603 OMIM: 620782 GeneReviews: Not available
not available

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2024-07-24)

ClinGen Genome Curation Page
Haploinsufficency

Little evidence for dosage pathogenicity (Last evaluated 2024-07-24)

ClinGen Genome Curation PagePubMed

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify cell cycle associated protein 1 (CAPRIN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify cell cycle associated protein 1 (CAPRIN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify cell cycle associated protein 1 (CAPRIN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify cell cycle associated protein 1 (CAPRIN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Rev rev HIV-1 Rev interacting protein, cell cycle associated protein 1 (CAPRIN1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with CAPRIN1 is increased by RRE PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables molecular condensate scaffold activity IDA
Inferred from Direct Assay
more info
PubMed 
enables molecular function activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in P-body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic stress granule ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
is_active_in intracellular membraneless organelle IDA
Inferred from Direct Assay
more info
PubMed 
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
 
located_in membrane HDA PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
caprin-1
Names
GPI-anchored membrane protein 1
GPI-anchored protein p137
GPI-p137
RNA granule protein 105
activation/proliferation-associated protein 1
caprin 1
cytoplasmic activation- and proliferation-associated protein 1
cytoplasmic activation/proliferation-associated protein-1
membrane component chromosome 11 surface marker 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005898.5NP_005889.3  caprin-1 isoform 1

    See identical proteins and their annotated locations for NP_005889.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC090469
    Consensus CDS
    CCDS31453.1
    UniProtKB/Swiss-Prot
    A6NMY7, D3DR06, Q14444, Q15074, Q6IMN4, Q6IMN7, Q9BV09
    UniProtKB/TrEMBL
    B3KXU8
    Related
    ENSP00000340329.4, ENST00000341394.9
    Conserved Domains (3) summary
    COG0419
    Location:52198
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    pfam12287
    Location:359681
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    pfam18293
    Location:132247
    Caprin-1_dimer; Caprin-1 dimerization domain
  2. NM_203364.3NP_976240.1  caprin-1 isoform 2

    See identical proteins and their annotated locations for NP_976240.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding region compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC090469
    Consensus CDS
    CCDS31454.1
    UniProtKB/TrEMBL
    B3KXU8
    Related
    ENSP00000374296.3, ENST00000389645.7
    Conserved Domains (3) summary
    COG0419
    Location:52198
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    pfam12287
    Location:359685
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    pfam18293
    Location:132247
    Caprin-1_dimer; Caprin-1 dimerization domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    34051731..34102610
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426960.1XP_047282916.1  caprin-1 isoform X1

  2. XM_047426959.1XP_047282915.1  caprin-1 isoform X2

    UniProtKB/Swiss-Prot
    A6NMY7, D3DR06, Q14444, Q15074, Q6IMN4, Q6IMN7, Q9BV09
    UniProtKB/TrEMBL
    B3KXU8
    Related
    ENSP00000434150.1, ENST00000532820.5
  3. XM_047426961.1XP_047282917.1  caprin-1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    34188759..34239614
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368807.1XP_054224782.1  caprin-1 isoform X1