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CAPRIN1 cell cycle associated protein 1 [ Homo sapiens (human) ]

Gene ID: 4076, updated on 3-May-2020

Summary

Official Symbol
CAPRIN1provided by HGNC
Official Full Name
cell cycle associated protein 1provided by HGNC
Primary source
HGNC:HGNC:6743
See related
Ensembl:ENSG00000135387 MIM:601178
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
M11S1; GPIAP1; RNG105; GPIP137; GRIP137; p137GPI
Expression
Ubiquitous expression in testis (RPKM 43.8), brain (RPKM 23.0) and 25 other tissues See more
Orthologs

Genomic context

See CAPRIN1 in Genome Data Viewer
Location:
11p13
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (34051663..34102610)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (34073230..34124157)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr11.1734 Neighboring gene VISTA enhancer hs1858 Neighboring gene uncharacterized LOC101929918 Neighboring gene N-acetyltransferase 10 Neighboring gene uncharacterized LOC102723539 Neighboring gene ankyrin repeat and BTB domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify cell cycle associated protein 1 (CAPRIN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify cell cycle associated protein 1 (CAPRIN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify cell cycle associated protein 1 (CAPRIN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify cell cycle associated protein 1 (CAPRIN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Rev rev HIV-1 Rev interacting protein, cell cycle associated protein 1 (CAPRIN1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with CAPRIN1 is increased by RRE PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of translation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of dendrite morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
P-body ISS
Inferred from Sequence or Structural Similarity
more info
 
cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic stress granule ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
caprin-1
Names
GPI-anchored membrane protein 1
GPI-anchored protein p137
GPI-p137
RNA granule protein 105
activation/proliferation-associated protein 1
caprin 1
cytoplasmic activation- and proliferation-associated protein 1
cytoplasmic activation/proliferation-associated protein-1
membrane component chromosome 11 surface marker 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005898.5NP_005889.3  caprin-1 isoform 1

    See identical proteins and their annotated locations for NP_005889.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC090469
    Consensus CDS
    CCDS31453.1
    UniProtKB/Swiss-Prot
    Q14444
    Related
    ENSP00000340329.4, ENST00000341394.9
    Conserved Domains (2) summary
    COG0419
    Location:52198
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    pfam12287
    Location:359681
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
  2. NM_203364.3NP_976240.1  caprin-1 isoform 2

    See identical proteins and their annotated locations for NP_976240.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding region compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC090469
    Consensus CDS
    CCDS31454.1
    UniProtKB/Swiss-Prot
    Q14444
    Related
    ENSP00000374296.3, ENST00000389645.7
    Conserved Domains (2) summary
    pfam12287
    Location:359685
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    cl25732
    Location:52198
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    34051663..34102610
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_930869.3 RNA Sequence

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