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EGFR epidermal growth factor receptor [ Bos taurus (domestic cattle) ]

Gene ID: 407217, updated on 30-Jan-2025
Official Symbol
EGFRprovided by VGNC
Official Full Name
epidermal growth factor receptorprovided by VGNC
Primary source
VGNC:VGNC:28366
See related
BGD:BT10403; EnsemblRapid:ENSBTAG00070019933
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See EGFR in Genome Data Viewer
Location:
chromosome: 22
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (904065..1121545, complement)

Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene LanC like glutathione S-transferase 2 Neighboring gene uncharacterized LOC112443455 Neighboring gene uncharacterized LOC112443529 Neighboring gene large ribosomal subunit protein uL22-like

Genomic Sequence:
NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Regulation of the aryl hydrocarbon receptor activity in bovine cumulus-oocyte complexes during in vitro maturation: The role of EGFR and post-EGFR ERK1/2 signaling cascade. Pocar P, et al. Theriogenology, 2020 Oct 15. PMID 32679457
  2. Expression of the erbB/HER receptor family in the bovine uterus during the sexual cycle and the relation of this family to serum sex steroids. Sağsöz H, et al. Biotech Histochem, 2012 Feb. PMID 21299369
  3. Regulation of the sperm EGF receptor by ouabain leads to initiation of the acrosome reaction. Daniel L, et al. Dev Biol, 2010 Aug 15. PMID 20580701
  4. Bovine sperm acrosome reaction induced by G-protein-coupled receptor agonists is mediated by epidermal growth factor receptor transactivation. Etkovitz N, et al. Dev Biol, 2009 Oct 15. PMID 19666015
  5. The Role of Epidermal Growth Factor Receptor Signaling Pathway during Bovine Herpesvirus 1 Productive Infection in Cell Culture. Qiu W, et al. Viruses, 2020 Aug 24. PMID 32846937, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. External and internal EGFR-activating signals drive mammary epithelial cells proliferation and viability.
    Title: External and internal EGFR-activating signals drive mammary epithelial cells proliferation and viability.
  2. Regulation of the aryl hydrocarbon receptor activity in bovine cumulus-oocyte complexes during in vitro maturation: The role of EGFR and post-EGFR ERK1/2 signaling cascade.
    Title: Regulation of the aryl hydrocarbon receptor activity in bovine cumulus-oocyte complexes during in vitro maturation: The role of EGFR and post-EGFR ERK1/2 signaling cascade.
  3. The Role of Epidermal Growth Factor Receptor Signaling Pathway during Bovine Herpesvirus 1 Productive Infection in Cell Culture.
    Title: The Role of Epidermal Growth Factor Receptor Signaling Pathway during Bovine Herpesvirus 1 Productive Infection in Cell Culture.
  4. Stimulation of bovine oviduct epithelial cell EGFR with EGF (human recombinant EGF) alone or with EGF in postovulatory/follicular phases (not luteal phase) up-regulates phosphorylation of MAPKs; heat blocks effects of EGF on phosphorylation of MAPKs.
    Title: Effect of epidermal growth factor (EGF) on the phosphorylation of mitogen-activated protein kinase (MAPK) in the bovine oviduct in vitro: Alteration by heat stress.
  5. Expression of the erbB/HER receptor family in the bovine uterus during the sexual cycle and the relation of this family to serum sex steroids.
    Title: Expression of the erbB/HER receptor family in the bovine uterus during the sexual cycle and the relation of this family to serum sex steroids.
  6. Regulation of the sperm EGFR by ouabain leads to initiation of the acrosome reaction.
    Title: Regulation of the sperm EGF receptor by ouabain leads to initiation of the acrosome reaction.
  7. EGFR may simultaneously activate c-Src and PI3K to amplify the oxytocin signaling to increase the output of PGF(2 alpha) in endometrial epithelial cells.
    Title: Epidermal growth factor receptor is an obligatory intermediate for oxytocin-induced cyclooxygenase 2 expression and prostaglandin F2 alpha production in bovine endometrial epithelial cells.
  8. EGFR is stimulated during capacitation via PKA activation. More activation induces the acrosome reaction, which is induced by GPCR via EGFR transactivation by a signaling pathway involving PKA, SRC & metalloproteinase & effectors PI3K, PLC & PKC.
    Title: Bovine sperm acrosome reaction induced by G-protein-coupled receptor agonists is mediated by epidermal growth factor receptor transactivation.
  9. possible cooperative role of the EGF and HGF pathways and indicate that cross-talk between their respective receptors may modulate mammary gland development in the cow
    Title: Epidermal growth factor and hepatocyte growth factor receptors collaborate to induce multiple biological responses in bovine mammary epithelial cells.
  10. Data suggest that epidermal growth factor (EGF) and EGF receptors are important paracrine and/or autocrine regulators of spermatogenesis in bovine.
    Title: Localization of the epidermal growth factor (EGF) and epidermal growth factor receptor (EGFR) in the bovine testis.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables epidermal growth factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables epidermal growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neurogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in basal plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
epidermal growth factor receptor
Names
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
XP_002696936.2

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    904065..1121545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002696890.6 → XP_002696936.2  epidermal growth factor receptor

    See identical proteins and their annotated locations for XP_002696936.2

    UniProtKB/TrEMBL
    A0A3Q1MHB0
    Related
    ENSBTAP00070027126.1, ENSBTAT00070045081.1
    Conserved Domains (8) summary
    smart00219
    Location:713 → 968
    TyrKc; Tyrosine kinase, catalytic domain
    smart00261
    Location:552 → 598
    FU; Furin-like repeats
    cd00064
    Location:231 → 274
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    cd05108
    Location:704 → 1016
    PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
    cl17045
    Location:634 → 677
    TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
    pfam00757
    Location:185 → 335
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:57 → 168
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:505 → 637
    GF_recep_IV; Growth factor receptor domain IV
Nucleotide Protein Strain
Heading Accession and Version

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