U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

BMP4 bone morphogenetic protein 4 [ Bos taurus (domestic cattle) ]

Gene ID: 407216, updated on 5-Sep-2025
Official Symbol
BMP4provided by VGNC
Official Full Name
bone morphogenetic protein 4provided by VGNC
Primary source
VGNC:VGNC:26519
See related
BGD:BT11191; EnsemblRapid:ENSBTAG00070011868
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table
See BMP4 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (66518533..66525639, complement)

Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC132346381 Neighboring gene transfer RNA serine (anticodon AGA) Neighboring gene small integral membrane protein 27

Genomic Sequence:
NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. A small set of extra-embryonic genes defines a new landmark for bovine embryo staging. Degrelle SA, et al. Reproduction, 2011 Jan. PMID 20926692
  2. Polymorphic CA microsatellites in the third exon of the bovine BMP4 gene. Zhong X, et al. Genet Mol Res, 2010 May 11. PMID 20467979
  3. Aberrant gene expression in organs of bovine clones that die within two days after birth. Li S, et al. Biol Reprod, 2005 Feb. PMID 15240423
  4. Bone morphogenetic protein 4 and retinoic acid trigger bovine VASA homolog expression in differentiating bovine induced pluripotent stem cells. Malaver-Ortega LF, et al. Mol Reprod Dev, 2016 Feb. PMID 26660942
  5. The expression and potential function of bone morphogenetic proteins 2 and 4 in bovine trophectoderm. Pennington KA, et al. Reprod Biol Endocrinol, 2012 Feb 13. PMID 22330732, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. data indicate that the pro-angiogenic activity exerted by BMP4 in endothelial cells is mediated by a BMPR-mediated intracellular transactivation of VEGFR2 via c-Src.
    Title: VEGFR2 activation mediates the pro-angiogenic activity of BMP4.
  2. High BMP4 expression is associated with cystic ovarian disease.
    Title: BMP2, 4 and 6 and BMPR1B are altered from early stages of bovine cystic ovarian disease development.
  3. Bone morphogenetic protein 4 and retinoic acid trigger bovine VASA homolog expression in differentiating bovine induced pluripotent stem cells.
    Title: Bone morphogenetic protein 4 and retinoic acid trigger bovine VASA homolog expression in differentiating bovine induced pluripotent stem cells.
  4. The BMP2/4 ligand and receptor system presides within bovine trophectoderm prior to uterine attachment. BMP4 negatively impacts CT1 cell growth
    Title: The expression and potential function of bone morphogenetic proteins 2 and 4 in bovine trophectoderm.
  5. BMP4 during maturation increased the proportion of Oct-4 positive cells in parthenogenic embryos. BMP4 is implicated in bovine oocytes maturation and embryo development.
    Title: Effects of bone morphogenic protein 4 (BMP4) and its inhibitor, Noggin, on in vitro maturation and culture of bovine preimplantation embryos.
  6. analysis of polymorphic CA microsatellites in the third exon of the bovine BMP4 gene
    Title: Polymorphic CA microsatellites in the third exon of the bovine BMP4 gene.
  7. Data report that BMP-7 suppresses granulosa cell apoptosis by inhibiting the release of caspase-activated DNase (CAD) via a mechanism which does not appear to be associated with the mitochondrial pathway, whereas BMP-4 inhibits the release of CAD.
    Title: The differential pathways of bone morphogenetic protein (BMP)-4 and -7 in the suppression of the bovine granulosa cell apoptosis.
  8. Heat shock protein 70 enhances vascular bone morphogenetic protein-4 signaling by binding matrix Gla protein.
    Title: Heat shock protein 70 enhances vascular bone morphogenetic protein-4 signaling by binding matrix Gla protein.
  9. concluded that a bone morphogenetic protein (BMP)-signaling system, consisting of BMP2, BMP4, type II and I receptors, is present in bovine antral follicles and plays a role in development and functioning of follicles rather than in oocyte maturation
    Title: Expression of bone morphogenetic protein2 (BMP2), BMP4 and BMP receptors in the bovine ovary but absence of effects of BMP2 and BMP4 during IVM on bovine oocyte nuclear maturation and subsequent embryo development.
Submit: New GeneRIF Correction

Markers

Homology

Clone Names

  • MGC127497

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
bone morphogenetic protein 4
Names
BMP-4

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045877.1 → NP_001039342.1  bone morphogenetic protein 4 precursor

    See identical proteins and their annotated locations for NP_001039342.1

    Status: PROVISIONAL

    Source sequence(s)
    BC105344
    UniProtKB/Swiss-Prot
    Q2KJH1
    UniProtKB/TrEMBL
    A0AAA9SZL8
    Conserved Domains (2) summary
    pfam00019
    Location:309 → 408
    TGF_beta; Transforming growth factor beta like domain
    pfam00688
    Location:41 → 276
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    66518533..66525639 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024997309.2 → XP_024853077.1  bone morphogenetic protein 4 isoform X1

    UniProtKB/TrEMBL
    Q5I4I9
    Related
    ENSBTAP00070015903.1, ENSBTAT00070026727.1
    Conserved Domains (2) summary
    smart00204
    Location:356 → 456
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:88 → 323
    TGFb_propeptide; TGF-beta propeptide
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2KJH1.1 GenPept UniProtKB/Swiss-Prot:Q2KJH1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.