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BSP1 binder of sperm 1 [ Bos taurus (domestic cattle) ]

Gene ID: 407187, updated on 30-Jan-2025
Gene symbol
BSP1
Gene description
binder of sperm 1
See related
EnsemblRapid:ENSBTAG00070017237
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
PDC109; PDC-109; SVSP109
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See BSP1 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (51618421..51622953)

Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene binder of sperm 5 Neighboring gene seminal plasma protein A3 Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene transfer RNA alanine (anticodon AGC)

Genomic Sequence:
NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Conformational dynamics and ligand binding in the multi-domain protein PDC109. Kim HJ, et al. PLoS One, 2010 Feb 18. PMID 20174627, Free PMC Article
  2. Refined solution structure and ligand-binding properties of PDC-109 domain b. A collagen-binding type II domain. Constantine KL, et al. J Mol Biol, 1992 Jan 5. PMID 1731074
  3. Characterization of the gene for the bovine seminal vesicle secretory protein SVSP109. Bräuer C, et al. Biochim Biophys Acta, 1991 Oct 8. PMID 1932121
  4. Sequence-specific 1H NMR assignments and structural characterization of bovine seminal fluid protein PDC-109 domain b. Constantine KL, et al. Biochemistry, 1991 Feb 12. PMID 1993183
  5. Cloning and sequence analysis of a cDNA from seminal vesicle tissue encoding the precursor of the major protein of bull semen. Kemme M, et al. DNA, 1988 Nov. PMID 3229283

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Conserved core tryptophans of FnII domains are crucial for the membranolytic and chaperone-like activities of bovine seminal plasma protein PDC-109.
    Title: Conserved core tryptophans of FnII domains are crucial for the membranolytic and chaperone-like activities of bovine seminal plasma protein PDC-109.
  2. Glycosylation decreases the membranolytic activity of PDC-109 but increases its chaperone-like activities.
    Title: Glycosylation differentially modulates membranolytic and chaperone-like activities of PDC-109, the major protein of bovine seminal plasma.
  3. PDC-109 binds to choline phospholipids of the sperm plasma membrane and induces an efflux of cholesterol and choline phospholipids, which is crucial for sperm capacitation. PDC-109 also exhibits chaperone-like activity and protects target proteins against various kinds of stress. Spermine and spermidine, present in high concentration in the seminal plasma, increase the ability of PDC-109 to perturb membrane structure.
    Title: Spermine and spermidine act as chemical chaperones and enhance chaperone-like and membranolytic activities of major bovine seminal plasma protein, PDC-109.
  4. This is the first report showing that more than two forms of BSP1 are found in the seminal plasma of Nelore adult bulls and not all animals have a similar abundance of each BSP1 form.
    Title: Differential abundances of four forms of Binder of SPerm 1 in the seminal plasma of Bos taurus indicus bulls with different patterns of semen freezability.
  5. abundant in bull sperm, more in low fertility group than in high fertility group
    Title: Profiling of sperm proteins and association of sperm PDC-109 with bull fertility.
  6. Data indicate the temperature dependence of the thermodynamics in the binding of PDC-109 to O-lauroylcholine and O-myristoylcholine.
    Title: Biophysical characterization of the interaction of O-acylcholines with the major bovine seminal plasma protein, PDC-109.
  7. Data suggest that binding of BSP1, BSP3, and BSP5 is increased on surface of bull sperm following cryopreservation; binder of sperm proteins appear to play roles in formation of oviductal sperm storage reservoir and in sperm capacitation.
    Title: Cryopreservation increases coating of bull sperm by seminal plasma binder of sperm proteins BSP1, BSP3, and BSP5.
  8. analysis of chemical and physical requirements for lipid extraction by bovine binder of sperm BSP1
    Title: Chemical and physical requirements for lipid extraction by bovine binder of sperm BSP1.
  9. The presence of BSP1 over the acrosomal region characterises spermatozoa sensitive to cryopreservation and ELSPBP1 characterises spermatozoa that are already dead at ejaculation.
    Title: Binder of sperm 1 and epididymal sperm binding protein 1 are associated with different bull sperm subpopulations.
  10. Large oligomeric structures are formed upon binding of PDC-109 to heparin, indicating an increase in the local density of the protein, which may be relevant to the ability of heparin to potentiate PDC-109 induced sperm capacitation.
    Title: Biophysical investigations on the interaction of the major bovine seminal plasma protein, PDC-109, with heparin.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in sperm capacitation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
seminal plasma protein PDC-109
Names
BSP-A1 and BSP-A2
seminal vesicle secretory protein 109

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001145.1 → NP_001001145.1  seminal plasma protein PDC-109 precursor

    See identical proteins and their annotated locations for NP_001001145.1

    Status: PROVISIONAL

    Source sequence(s)
    M22244
    UniProtKB/Swiss-Prot
    P02784
    UniProtKB/TrEMBL
    A0AAF6ZKY4
    Related
    ENSBTAP00070023022.1, ENSBTAT00070038831.1
    Conserved Domains (1) summary
    smart00059
    Location:87 → 134
    FN2; Fibronectin type 2 domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    51618421..51622953
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P02784.2 GenPept UniProtKB/Swiss-Prot:P02784

Gene LinkOut

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Molecular Biology Databases
Research Materials