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AGTR2 angiotensin II receptor type 2 [ Bos taurus (domestic cattle) ]

Gene ID: 407157, updated on 30-Jan-2025
Official Symbol
AGTR2provided by VGNC
Official Full Name
angiotensin II receptor type 2provided by VGNC
Primary source
VGNC:VGNC:25746
See related
BGD:BT26116; EnsemblRapid:ENSBTAG00070025674
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
at2
Orthologs
human mouse all
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See AGTR2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) X NC_037357.1 (543597..547783, complement)

Chromosome X - NC_037357.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101907514 Neighboring gene uncharacterized LOC100847612 Neighboring gene uncharacterized LOC132344359 Neighboring gene transfer RNA glycine (anticodon GCC) Neighboring gene solute carrier family 6 member 14

Genomic Sequence:
NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Regulation of angiotensin type 2 receptor in bovine granulosa cells. Portela VM, et al. Endocrinology, 2008 Oct. PMID 18583424
  2. Angiotensin II stimulates nitric oxide production in pulmonary artery endothelium via the type 2 receptor. Olson S, et al. Am J Physiol Lung Cell Mol Physiol, 2004 Sep. PMID 15155270
  3. Evidence for a local endothelin-angiotensin-atrial natriuretic peptide systemin bovine mature follicles in vitro: effects on steroid hormones and prostaglandin secretion. Acosta TJ, et al. Biol Reprod, 1999 Dec. PMID 10569984
  4. Preovulatory changes in the angiotensin II system in bovine follicles. Siqueira LC, et al. Reprod Fertil Dev, 2013. PMID 23464501
  5. Angiotensin II type 2 receptor-dependent increases in nitric oxide synthase expression in the pulmonary endothelium is mediated via a G alpha i3/Ras/Raf/MAPK pathway. Li J, et al. Am J Physiol Cell Physiol, 2007 Jun. PMID 17329403

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that AGTR2 (and angiotensin-converting enzyme) mRNA levels are transiently up-regulated in ovarian theca cells during preovulatory period.
    Title: Preovulatory changes in the angiotensin II system in bovine follicles.
  2. Abundance of AGTR2 mRNA in granulosa cells was higher in healthy compared with atretic follicles, whereas in theca cells, it did not change
    Title: Regulation of angiotensin type 2 receptor in bovine granulosa cells.
  3. endothelial, type 2 receptor-dependent increase in nitric oxide may serve to counterbalance the angiotensin II-dependent vasoconstriction in smooth muscle cells, ultimately regulating pulmonary vascular tone.
    Title: Angiotensin II stimulates nitric oxide production in pulmonary artery endothelium via the type 2 receptor.
  4. data suggest that G alpha(i3), Shc, Grb2, Ras, and Raf-1 link Src to activation of MAPK and to the AT(2)-dependent increase in eNOS expression in PAECs
    Title: Angiotensin II type 2 receptor-dependent increases in nitric oxide synthase expression in the pulmonary endothelium is mediated via a G alpha i3/Ras/Raf/MAPK pathway.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables C-C chemokine binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables C-C chemokine receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables angiotensin type II receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in blood vessel diameter maintenance IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in brain development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in calcium-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neurogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
type-2 angiotensin II receptor
Names
angiotensin receptor 2

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037357.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    543597..547783 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024988817.2 → XP_024844585.1  type-2 angiotensin II receptor

    UniProtKB/TrEMBL
    G5E6F7
    Conserved Domains (1) summary
    cd15191
    Location:44 → 328
    7tmA_AT2R; type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_010821316.4 → XP_010819618.1  type-2 angiotensin II receptor

    See identical proteins and their annotated locations for XP_010819618.1

    UniProtKB/TrEMBL
    G5E6F7
    Related
    ENSBTAP00070034585.1, ENSBTAT00070058140.1
    Conserved Domains (1) summary
    cd15191
    Location:44 → 328
    7tmA_AT2R; type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. XM_059883691.1 → XP_059739674.1  type-2 angiotensin II receptor

    UniProtKB/TrEMBL
    G5E6F7
Nucleotide Protein Strain
Heading Accession and Version

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