U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PTPRC protein tyrosine phosphatase receptor type C [ Bos taurus (domestic cattle) ]

Gene ID: 407152, updated on 5-Sep-2025
Official Symbol
PTPRCprovided by VGNC
Official Full Name
protein tyrosine phosphatase receptor type Cprovided by VGNC
Primary source
VGNC:VGNC:33546
See related
BGD:BT12319; EnsemblRapid:ENSBTAG00070007626
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
cd45
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table
See PTPRC in Genome Data Viewer
Location:
chromosome: 16
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 16 NC_037343.1 (77540603..77670102)

Chromosome 16 - NC_037343.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112441875 Neighboring gene uncharacterized LOC104974538 Neighboring gene U6 spliceosomal RNA Neighboring gene glycine cleavage system H protein, mitochondrial-like Neighboring gene uncharacterized LOC104974541 Neighboring gene microRNA mir-181b-1

Genomic Sequence:
NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Allelic Variation in Protein Tyrosine Phosphatase Receptor Type-C in Cattle Influences Erythrocyte, Leukocyte and Humoral Responses to Infestation With the Cattle Tick Rhipicephalus australis. Jonsson NN, et al. Front Immunol, 2021. PMID 34305905, Free PMC Article
  2. The CD45 locus in cattle: allelic polymorphism and evidence for exceptional positive natural selection. Ballingall KT, et al. Immunogenetics, 2001. PMID 11220630
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Allelic Variation in Protein Tyrosine Phosphatase Receptor Type-C in Cattle Influences Erythrocyte, Leukocyte and Humoral Responses to Infestation With the Cattle Tick Rhipicephalus australis.
    Title: Allelic Variation in Protein Tyrosine Phosphatase Receptor Type-C in Cattle Influences Erythrocyte, Leukocyte and Humoral Responses to Infestation With the Cattle Tick Rhipicephalus australis.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in synaptic membrane adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
receptor-type tyrosine-protein phosphatase C
Names
membrane tyrosine phosphatase
NP_001193452.1

Length

  • 1145
XP_005217387.1
XP_010811847.1
XP_010811849.1
XP_015330753.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001206523.1 → NP_001193452.1  receptor-type tyrosine-protein phosphatase C precursor

    Status: VALIDATED

    Source sequence(s)
    AAFC03001410, AAFC03104476, BC148881, EH207654
    UniProtKB/TrEMBL
    F1MJS9
    Related
    ENSBTAP00070010155.1, ENSBTAT00070017467.1
    Conserved Domains (6) summary
    smart00194
    Location:491 → 750
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:519 → 750
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:324 → 411
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:233 → 302
    fn3; Fibronectin type III domain
    pfam12453
    Location:7 → 32
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:73 → 126
    CD45; Leukocyte receptor CD45

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037343.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    77540603..77670102
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015475267.3 → XP_015330753.1  receptor-type tyrosine-protein phosphatase C isoform X3

    UniProtKB/TrEMBL
    A0AAA9U0X3, F1MJS9
    Conserved Domains (6) summary
    smart00194
    Location:491 → 750
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:519 → 750
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:324 → 411
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:233 → 302
    fn3; Fibronectin type III domain
    pfam12453
    Location:7 → 32
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:73 → 126
    CD45; Leukocyte receptor CD45

  2. XM_005217330.5 → XP_005217387.1  receptor-type tyrosine-protein phosphatase C isoform X1

    UniProtKB/TrEMBL
    A0AAA9S9Q3, F1MJS9
    Related
    ENSBTAP00070010082.1, ENSBTAT00070017360.1
    Conserved Domains (8) summary
    smart00194
    Location:681 → 940
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:709 → 940
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:514 → 601
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:423 → 492
    fn3; Fibronectin type III domain
    pfam12453
    Location:7 → 32
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:263 → 316
    CD45; Leukocyte receptor CD45
    pfam16612
    Location:27 → 141
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16788
    Location:113 → 190
    ATF7IP_BD; ATF-interacting protein binding domain

  3. XM_010813545.4 → XP_010811847.1  receptor-type tyrosine-protein phosphatase C isoform X2

    UniProtKB/TrEMBL
    A0AAA9SPC6, F1MJS9
    Related
    ENSBTAP00070010100.1, ENSBTAT00070017391.1
    Conserved Domains (7) summary
    smart00194
    Location:914 → 1196
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:650 → 881
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:455 → 542
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:364 → 433
    fn3; Fibronectin type III domain
    pfam12453
    Location:7 → 32
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:204 → 257
    CD45; Leukocyte receptor CD45
    cl25495
    Location:54 → 193
    Endomucin; Endomucin

  4. XM_010813547.4 → XP_010811849.1  receptor-type tyrosine-protein phosphatase C isoform X4

    UniProtKB/TrEMBL
    F1MJS9
    Conserved Domains (6) summary
    smart00194
    Location:759 → 1041
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:495 → 726
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:300 → 387
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:209 → 278
    fn3; Fibronectin type III domain
    pfam12453
    Location:7 → 32
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:49 → 102
    CD45; Leukocyte receptor CD45
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials