BMPR2 bone morphogenetic protein receptor type 2 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: BMPR2provided by VGNC
Official Full Name: bone morphogenetic protein receptor type 2provided by VGNC
Primary source: VGNC:VGNC:26526
See related: EnsemblRapid:ENSBTAG00070010561
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: bmprii
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	2	NC_037329.1 (90864689..91017391)

Chromosome 2 - NC_037329.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

COMP regulation of BMPR2 appears to have an important role in controlling hypoxia-elicited changes in pulmonary artery superoxide and its potential regulation of contractile phenotype proteins.
Title: Potential role of cartilage oligomeric matrix protein in the modulation of pulmonary arterial smooth muscle superoxide by hypoxia.
Inhibition of BMPR2 resulted in increased expression of ALK4 and decreased expression of PTX3, HAS2 and PTGS2.
Title: Effects of MiR-375-BMPR2 as a Key Factor Downstream of BMP15/GDF9 on the Smad1/5/8 and Smad2/3 Signaling Pathways.
These findings are important because Wnt, BMPR2, and Akt3 promote neurogenesis and cell survival, processes crucial for lifelong viral latency.
Title: The Wnt Signaling Pathway Is Differentially Expressed during the Bovine Herpesvirus 1 Latency-Reactivation Cycle: Evidence That Two Protein Kinases Associated with Neuronal Survival, Akt3 and BMPR2, Are Expressed at Higher Levels during Latency.
the miR-17-92 cluster is involved in granulosa cell proliferation and differentiation by coordinately targeting the PTEN and BMPR2 genes.
Title: MicroRNA 17-92 cluster regulates proliferation and differentiation of bovine granulosa cells by targeting PTEN and BMPR2 genes.
Genetic variability is an important component of the number of antral follicles in the bovine ovary.
Title: Single nucleotide polymorphisms in the bovine genome are associated with the number of oocytes collected during ovum pick up.
Stimulation of BMPRII promotes normal pulmonary artery endothelial cell function by activating eNOS.
Title: Bone morphogenetic protein receptor II is a novel mediator of endothelial nitric-oxide synthase activation.

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General gene information

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Markers

MARC_17227-17228:1023899664:1 (e-PCR)
- UniSTS:268259

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables transforming growth factor beta receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in blood vessel development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to growth factor stimulus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
part_of receptor complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: bone morphogenetic protein receptor type-2

Names: bone morphogenetic protein receptor, type II (serine/threonine kinase)

NP_001291214.1

EC 2.7.11.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001304285.2 → NP_001291214.1 bone morphogenetic protein receptor type-2 precursor

Status: PROVISIONAL

Source sequence(s)

NKLS02000002

UniProtKB/TrEMBL

A0A3Q1LP90

Related

ENSBTAP00070013998.1, ENSBTAT00070023649.1

Conserved Domains (3) summary

smart00220
Location:204 → 495

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14054
Location:207 → 504

STKc_BMPR2_AMHR2; Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors

pfam01064
Location:60 → 131

Activin_recp; Activin types I and II receptor domain