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Sym Symplekin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40709, updated on 23-Jul-2026
Official Symbol
Symprovided by FlyBase
Official Full Name
Symplekinprovided by FlyBase
Primary source
FLYBASE:FBgn0037371
Locus tag
Dmel_CG2097
See related
AllianceGenome:FB:FBgn0037371
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2097; Dmel\CG2097; dSymp; Symp; symplekin
Summary
Involved in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway and mRNA 3'-end processing by stem-loop binding activity and cleavage. Located in histone locus body and tricellular tight junction. Part of mRNA cleavage and polyadenylation specificity factor complex. Is expressed in organism and spermatozoon. Orthologous to human SYMPK (symplekin scaffold protein). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See Sym in Genome Data Viewer
Location:
83C1-83C2; 3-47.5 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5738178..5742476, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1563900..1568198, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene MLF1-adaptor molecule Neighboring gene Decapping enzyme, scavenger

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Crystal structure of the HEAT domain from the Pre-mRNA processing factor Symplekin. Kennedy SA, et al. J Mol Biol, 2009 Sep 11. PMID 19576221, Free PMC Article
  2. novel modifications on C-terminal domain of RNA polymerase II can fine-tune the phosphatase activity of Ssu72. Luo Y, et al. ACS Chem Biol, 2013 Sep 20. PMID 23844594, Free PMC Article
  3. In vivo characterization of the Drosophila mRNA 3' end processing core cleavage complex. Michalski D, et al. RNA, 2015 Aug. PMID 26081560, Free PMC Article
  4. Structural determinants for accurate dephosphorylation of RNA polymerase II by its cognate C-terminal domain (CTD) phosphatase during eukaryotic transcription. Irani S, et al. J Biol Chem, 2019 May 24. PMID 30971428, Free PMC Article
  5. Drosophila melanogaster retrotransposon and inverted repeat-derived endogenous siRNAs are differentially processed in distinct cellular locations. Harrington AW, et al. BMC Genomics, 2017 Apr 17. PMID 28415970, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Authors propose a model in which the core cleavage complex formation is mediated by CPSF73, CPSF100, and Symplekin C-termini, and the N-terminal region of Symplekin facilitates cotranscriptional 3' end processing of histone mRNAs.
    Title: In vivo characterization of the Drosophila mRNA 3' end processing core cleavage complex.
  2. This localization depends on the RNA binding protein ypsilon schachtel. CPSF-73 and a number of mRNAs are localized at this same site, suggesting that Symplekin participates in cytoplasmic polyadenylation at tricellular junctions.
    Title: Drosophila Symplekin localizes dynamically to the histone locus body and tricellular junctions.
  3. Together, these data support the conclusion that the Symplekin HEAT domain serves as a scaffold for protein-protein interactions essential to the mRNA maturation process.
    Title: Crystal structure of the HEAT domain from the Pre-mRNA processing factor Symplekin.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA 3'-end processing by stem-loop binding and cleavage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear histone mRNA catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in histone locus body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in histone locus body IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mRNA cleavage and polyadenylation specificity factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mRNA cleavage and polyadenylation specificity factor complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mRNA cleavage factor complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in tricellular tight junction IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
symplekin
Names
CG2097-PA
Sym-PA

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    5738178..5742476 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141323.2 → NP_649580.1  symplekin

    See identical proteins and their annotated locations for NP_649580.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MSU4, Q9VNH4
    Related
    FBpp0078372
    Conserved Domains (2) summary
    pfam11935
    Location:115 → 345
    DUF3453; Domain of unknown function (DUF3453)
    pfam12295
    Location:887 → 1067
    Symplekin_C; Symplekin tight junction protein C terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MSU4.1 Q8MSU4

Gene LinkOut

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