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klhl31 kelch-like family member 31 [ Danio rerio (zebrafish) ]

Gene ID: 407079, updated on 27-Mar-2024

Summary

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Official Symbol
klhl31provided by ZNC
Official Full Name
kelch-like family member 31provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2052
See related
Ensembl:ENSDARG00000039066 AllianceGenome:ZFIN:ZDB-GENE-030131-2052
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
klhl; kbtbd1; wu:fa31h10; wu:fb95e08
Summary
Predicted to act upstream of or within negative regulation of protein phosphorylation. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human KLHL31 (kelch like family member 31). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 13
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (2338695..2350307)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (2303718..2315309, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 1 Neighboring gene elongin A, like Neighboring gene glutamate-cysteine ligase, catalytic subunit Neighboring gene ELOVL fatty acid elongase 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. An integrated approach for the systematic identification and characterization of heart-enriched genes with unknown functions. Uchida S, et al. BMC Genomics, 2009 Mar 6. PMID 19267916, Free PMC Article
  2. A novel zebrafish kelchlike gene klhl and its human ortholog KLHL display conserved expression patterns in skeletal and cardiac muscles. Wu YL, et al. Gene, 2004 Aug 18. PMID 15302408
  3. Loss of function of myosin chaperones triggers Hsf1-mediated transcriptional response in skeletal muscle cells. Etard C, et al. Genome Biol, 2015 Dec 3. PMID 26631063, Free PMC Article
  4. Saltatory evolution of the ectodermal neural cortex gene family at the vertebrate origin. Feiner N, et al. Genome Biol Evol, 2013. PMID 23843192, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The expression pattern of klhl, as well as the presence of the kelch repeats indicates a possible role for Klhl in the organization of striated muscle cytoarchitecture.
    Title: A novel zebrafish kelchlike gene klhl and its human ortholog KLHL display conserved expression patterns in skeletal and cardiac muscles.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kelch-like protein 31
Names
kelch repeat and BTB (POZ) domain containing 1
kelch repeat and BTB domain-containing protein 1
kelch-like 31
kelch-like protein Klhl
kelchlike

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003727.3 → NP_001003727.1  kelch-like protein 31

    See identical proteins and their annotated locations for NP_001003727.1

    Status: VALIDATED

    Source sequence(s)
    CR376766
    UniProtKB/Swiss-Prot
    Q6Q7X9
    UniProtKB/TrEMBL
    A2RRU8
    Conserved Domains (6) summary
    smart00612
    Location:421 → 467
    Kelch; Kelch domain
    PHA03098
    Location:74 → 614
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:357 → 406
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:64 → 164
    BTB; BTB/POZ domain
    pfam01344
    Location:456 → 501
    Kelch_1; Kelch motif
    pfam07707
    Location:173 → 274
    BACK; BTB And C-terminal Kelch

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    2338695..2350307
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005156491.4 → XP_005156548.1  kelch-like protein 31 isoform X1

    UniProtKB/Swiss-Prot
    Q6Q7X9
    UniProtKB/TrEMBL
    A2RRU8
    Related
    ENSDARP00000093566.2, ENSDART00000102791.4
    Conserved Domains (6) summary
    smart00612
    Location:421 → 467
    Kelch; Kelch domain
    PHA03098
    Location:74 → 614
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:357 → 406
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:64 → 164
    BTB; BTB/POZ domain
    pfam01344
    Location:456 → 501
    Kelch_1; Kelch motif
    pfam07707
    Location:173 → 274
    BACK; BTB And C-terminal Kelch
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6Q7X9.1 GenPept UniProtKB/Swiss-Prot:Q6Q7X9

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