U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

emc2 ER membrane protein complex subunit 2 [ Danio rerio (zebrafish) ]

Gene ID: 407073, updated on 9-Sep-2025
Official Symbol
emc2provided by ZNC
Official Full Name
ER membrane protein complex subunit 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040625-82
See related
Ensembl:ENSDARG00000003308 AllianceGenome:ZFIN:ZDB-GENE-040625-82
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ttc35; zgc:73154; zgc:86891
Summary
Predicted to contribute to membrane insertase activity. Predicted to be involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Predicted to be located in endoplasmic reticulum membrane. Predicted to be extrinsic component of endoplasmic reticulum membrane. Predicted to be part of EMC complex. Orthologous to human EMC2 (ER membrane protein complex subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table
See emc2 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 16 NC_133191.1 (43066657..43136744)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 16 NC_007127.7 (38659524..38729600)

Chromosome 16 - NC_133191.1Genomic Context describing neighboring genes Neighboring gene R-spondin 2 Neighboring gene uncharacterized LOC141378296 Neighboring gene eukaryotic translation initiation factor 3, subunit E, a Neighboring gene thyrotropin-releasing hormone receptor a Neighboring gene transmembrane protein 74 Neighboring gene uncharacterized LOC141378298 Neighboring gene uncharacterized LOC137496203

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Syntabulin, a motor protein linker, controls dorsal determination. Nojima H, et al. Development, 2010 Mar. PMID 20150281
  2. Atp7b deficiency induces zebrafish eye developmental defects. Wu Y, et al. Metallomics, 2023 May 2. PMID 37070960
  3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Clone Names

  • KIAA0103

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
contributes_to membrane insertase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tail-anchored membrane protein insertion into ER membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of EMC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of EMC complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in extrinsic component of endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
ER membrane protein complex subunit 2
Names
TPR repeat protein 35
tetratricopeptide repeat domain 35
tetratricopeptide repeat protein 35

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213544.1 → NP_998709.1  ER membrane protein complex subunit 2

    See identical proteins and their annotated locations for NP_998709.1

    Status: PROVISIONAL

    Source sequence(s)
    AY398368
    UniProtKB/Swiss-Prot
    Q6TGY8
    Related
    ENSDARP00000006378.9, ENSDART00000023238.10
    Conserved Domains (3) summary
    sd00006
    Location:87 → 115
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:156 → 222
    TPR_11; TPR repeat
    pfam14559
    Location:97 → 164
    TPR_19; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133191.1 Reference GRCz12tu Primary Assembly

    Range
    43066657..43136744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6TGY8.1 GenPept UniProtKB/Swiss-Prot:Q6TGY8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools