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MIR92A2 microRNA 92a-2 [ Homo sapiens (human) ]

Gene ID: 407049, updated on 12-Oct-2019

Summary

Official Symbol
MIR92A2provided by HGNC
Official Full Name
microRNA 92a-2provided by HGNC
Primary source
HGNC:HGNC:31644
See related
Ensembl:ENSG00000284538 miRBase:MI0000094
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIRN92-2; MIRN92A2; MIRN92A-2; mir-92a-2
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Genomic context

See MIR92A2 in Genome Data Viewer
Location:
Xq26.2
Exon count:
1
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (134169538..134169612, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (133303568..133303642, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene translocase of inner mitochondrial membrane 8B pseudogene 2 Neighboring gene microRNA 363 Neighboring gene microRNA 19b-2 Neighboring gene microRNA 20b

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • Parkinsons Disease Pathway, organism-specific biosystem (from WikiPathways)
    Parkinsons Disease Pathway, organism-specific biosystemMost people with Parkinson's disease have idiopathic Parkinson's disease (having no specific known cause). A small proportion of cases, however, can be attributed to known genetic factors. Mutations ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Other Names

  • hsa-mir-92-2
  • hsa-mir-92a-2
  • microRNA 92-2

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cellular response to fatty acid ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to low-density lipoprotein particle stimulus IDA
Inferred from Direct Assay
more info
PubMed 
gene silencing by miRNA IDA
Inferred from Direct Assay
more info
PubMed 
gene silencing by miRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
miRNA mediated inhibition of translation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of JUN kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of blood vessel diameter ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of blood vessel endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of collagen biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT negative regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of endothelial cell-matrix adhesion via fibronectin IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of hydrogen peroxide-induced cell death ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of smooth muscle cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of acute inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of endothelial cell activation IC
Inferred by Curator
more info
PubMed 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of leukocyte adhesion to arterial endothelial cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of leukocyte adhesion to vascular endothelial cell IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of leukocyte adhesion to vascular endothelial cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of metalloendopeptidase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of metalloendopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of monocyte chemotactic protein-1 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of necrotic cell death ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of heart contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
vascular endothelial cell response to fluid shear stress IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular space HDA PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_029509.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC002407
    Related
    ENST00000385299.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    134169538..134169612 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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