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MIR92A1 microRNA 92a-1 [ Homo sapiens (human) ]

Gene ID: 407048, updated on 13-Nov-2022

Summary

Official Symbol
MIR92A1provided by HGNC
Official Full Name
microRNA 92a-1provided by HGNC
Primary source
HGNC:HGNC:31643
See related
Ensembl:ENSG00000283705 MIM:609422; miRBase:MI0000093; AllianceGenome:HGNC:31643
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIRH1; MIRHG1; MIR17HG; MIR92-1; C13orf25; MIRN92-1; MIRN92A1; MIRN92A-1; miRNA92-1; mir-92a-1
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

See MIR92A1 in Genome Data Viewer
Location:
13q31.3
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (91351314..91351391)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (90553890..90553967)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (92003568..92003645)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903189 Neighboring gene miR-17-92a-1 cluster host gene Neighboring gene microRNA 19b-1 Neighboring gene microRNA 20a Neighboring gene glypican 5 Neighboring gene RNA, U4atac small nuclear 3, pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Other Names

  • Putative microRNA 17 host gene protein
  • Putative microRNA host gene 1 protein
  • hsa-mir-92-1
  • hsa-mir-92a-1
  • microRNA 92-1

Gene Ontology Provided by GOA

Process Evidence Code Pubs
acts_upstream_of blood vessel diameter maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to fatty acid ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to low-density lipoprotein particle stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular stress response to acid chemical IDA
Inferred from Direct Assay
more info
PubMed 
involved_in miRNA-mediated gene silencing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in miRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
 
involved_in miRNA-mediated gene silencing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in miRNA-mediated gene silencing by inhibition of translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of JUN kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of blood vessel endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of collagen biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT involved_in negative regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of endothelial cell-matrix adhesion via fibronectin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of hydrogen peroxide-induced cell death ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of smooth muscle cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of acute inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of endothelial cell activation IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of leukocyte adhesion to arterial endothelial cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of leukocyte adhesion to vascular endothelial cell IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of leukocyte adhesion to vascular endothelial cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of metalloendopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of monocyte chemotactic protein-1 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of necrotic cell death ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of heart contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in vascular endothelial cell response to fluid shear stress IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032702.1 RefSeqGene

    Range
    8495..8572
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. NR_029508.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AL162375
    Related
    ENST00000385233.3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    91351314..91351391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    90553890..90553967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)