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MIR9-1 microRNA 9-1 [ Homo sapiens (human) ]

Gene ID: 407046, updated on 13-Nov-2022

Summary

Official Symbol
MIR9-1provided by HGNC
Official Full Name
microRNA 9-1provided by HGNC
Primary source
HGNC:HGNC:31641
See related
Ensembl:ENSG00000207933 MIM:611186; miRBase:MI0000466; AllianceGenome:HGNC:31641
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIRN9-1; mir-9-1; miRNA9-1; hsa-mir-9-1
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

See MIR9-1 in Genome Data Viewer
Location:
1q22
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (156420341..156420429, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (155558945..155559033, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156390133..156390221, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 198 Neighboring gene CRISPRi-validated cis-regulatory element chr1.9068 Neighboring gene MIR9-1 host gene Neighboring gene myocyte enhancer factor 2D Neighboring gene small nucleolar RNA U13 Neighboring gene IQ motif containing GTPase activating protein 3

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables high-density lipoprotein particle binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA base-pairing translational repressor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables single-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA-mediated gene silencing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in miRNA-mediated gene silencing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in miRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
 
involved_in miRNA-mediated gene silencing by inhibition of translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in miRNA-mediated gene silencing by mRNA destabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of NIK/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cholesterol efflux IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of lipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of osteoblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of receptor signaling pathway via JAK-STAT IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of transporter activity IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of negative regulation of xenobiotic detoxification by transmembrane export across the plasma membrane IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of positive regulation of lymphangiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of RISC complex IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_029691.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AL139130
    Related
    ENST00000385198.3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    156420341..156420429 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    155558945..155559033 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)