Format

Send to:

Choose Destination

MIR34A microRNA 34a [ Homo sapiens (human) ]

Gene ID: 407040, updated on 13-Jun-2021

Summary

Official Symbol
MIR34Aprovided by HGNC
Official Full Name
microRNA 34aprovided by HGNC
Primary source
HGNC:HGNC:31635
See related
Ensembl:ENSG00000284357 MIM:611172; miRBase:MI0000268
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
mir-34; MIRN34A; mir-34a; miRNA34A
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. This miRNA is a member of the highly conserved miR-34 family. This miRNA functions as a tumor suppressor and dysregulation or loss of the host gene from which this miRNA is processed is associated with cancer progression in numerous cell types. [provided by RefSeq, Sep 2015]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See MIR34A in Genome Data Viewer
Location:
1p36.22; 1p36.22
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (9151668..9151777, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (9211727..9211836, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 157 Neighboring gene Sharpr-MPRA regulatory region 7425 Neighboring gene MIR34A host gene Neighboring gene long non coding transcriptional activator of miR34a Neighboring gene hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Other Names

  • hsa-mir-34a

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cholesterol homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in gene silencing by miRNA HDA PubMed 
involved_in gene silencing by miRNA IDA
Inferred from Direct Assay
more info
PubMed 
involved_in gene silencing by miRNA IEA
Inferred from Electronic Annotation
more info
 
involved_in gene silencing by miRNA IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of B cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of amyloid-beta clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of calcium ion import IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of intracellular signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of lipid transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of peroxisome proliferator activated receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein kinase B signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of negative regulation of protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of smooth muscle cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of sprouting angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of negative regulation of transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of vascular associated smooth muscle cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of vascular associated smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of vascular endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of vascular endothelial growth factor production HMP PubMed 
involved_in negative regulation of vascular wound healing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of blood vessel endothelial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cardiac muscle cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cellular senescence IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of connective tissue replacement ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of hydrogen peroxide-induced cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of positive regulation of lipid storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein acetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of smooth muscle cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to axon injury ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in triglyceride homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in tumor necrosis factor-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_029610.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AL591166
    Related
    ENST00000385130.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    9151668..9151777 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center