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MIR30C1 microRNA 30c-1 [ Homo sapiens (human) ]

Gene ID: 407031, updated on 17-Jun-2024

Summary

Official Symbol
MIR30C1provided by HGNC
Official Full Name
microRNA 30c-1provided by HGNC
Primary source
HGNC:HGNC:31626
See related
Ensembl:ENSG00000207962 MIM:615151; miRBase:MI0000736; AllianceGenome:HGNC:31626
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIRN30C1; mir-30c-1
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

See MIR30C1 in Genome Data Viewer
Location:
1p34.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (40757284..40757372)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (40626494..40626582)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (41222956..41223044)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene regulating synaptic membrane exocytosis 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 850 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 851 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 852 Neighboring gene NFYC antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 733 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:41174578-41175204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41180095-41180734 Neighboring gene nuclear transcription factor Y subunit gamma Neighboring gene ATAC-STARR-seq lymphoblastoid active region 854 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 853 Neighboring gene microRNA 30e Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41253587-41254086 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:41267963-41268147 Neighboring gene potassium voltage-gated channel subfamily Q member 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41279047-41279546 Neighboring gene RNA, 7SL, cytoplasmic 326, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 855 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 735 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41286429-41286930 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:41290219-41291122 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41300271-41300796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41305349-41305957 Neighboring gene uncharacterized LOC105378676 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 856

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Other Names

  • hsa-mir-30c-1
  • miR-30c

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cellular response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cholesterol homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in miRNA-mediated post-transcriptional gene silencing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in miRNA-mediated post-transcriptional gene silencing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of negative regulation of cholesterol biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of negative regulation of fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of lipid transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of phospholipid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of protein secretion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of transformation of host cell by virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of triglyceride biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of triglyceride transport IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_029833.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AL354914
    Related
    ENST00000385227.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    40757284..40757372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    40626494..40626582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)