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MIR30B microRNA 30b [ Homo sapiens (human) ]

Gene ID: 407030, updated on 23-Oct-2022

Summary

Official Symbol
MIR30Bprovided by HGNC
Official Full Name
microRNA 30bprovided by HGNC
Primary source
HGNC:HGNC:31625
See related
Ensembl:ENSG00000207582 MIM:619018; miRBase:MI0000441; AllianceGenome:HGNC:31625
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIRN30B; mir-30b
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

See MIR30B in Genome Data Viewer
Location:
8q24.22
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (134800520..134800607, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (135918411..135918498, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (135812763..135812850, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene zinc finger and AT-hook domain containing Neighboring gene uncharacterized LOC124902072 Neighboring gene uncharacterized LOC124902071 Neighboring gene microRNA 30d Neighboring gene non-protein coding RNA 250

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Other Names

  • hsa-mir-30b

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mRNA base-pairing translational repressor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in miRNA-mediated gene silencing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in miRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
 
involved_in miRNA-mediated gene silencing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of dendritic spine maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of endothelial cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of long-term synaptic potentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of mini excitatory postsynaptic potential ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of regulatory T cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of vascular endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of activated T cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of RISC complex IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular vesicle HDA PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_029666.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC083843
    Related
    ENST00000384850.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    134800520..134800607 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    135918411..135918498 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)