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MIR29B1 microRNA 29b-1 [ Homo sapiens (human) ]

Gene ID: 407024, updated on 6-Nov-2022

Summary

Official Symbol
MIR29B1provided by HGNC
Official Full Name
microRNA 29b-1provided by HGNC
Primary source
HGNC:HGNC:31619
See related
Ensembl:ENSG00000283797 MIM:610783; miRBase:MI0000105; AllianceGenome:HGNC:31619
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
miR-29b; MIRN29B1; miRNA29B1; mir-29b-1
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

See MIR29B1 in Genome Data Viewer
Location:
7q32.3
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (130877459..130877539, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (132194951..132195031, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (130562218..130562298, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 3918 Neighboring gene long intergenic non-protein coding RNA, p53 induced transcript Neighboring gene microRNA 29a Neighboring gene Sharpr-MPRA regulatory region 2521 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancers GRCh37_chr7:130595421-130595954 and GRCh37_chr7:130595955-130596488

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Other Names

  • hsa-mir-29b-1

Gene Ontology Provided by GOA

Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in miRNA-mediated gene silencing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in miRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
 
involved_in miRNA-mediated gene silencing IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in miRNA-mediated gene silencing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in miRNA-mediated gene silencing by inhibition of translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of G1/S transition of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of NIK/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of amyloid precursor protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of amyloid-beta formation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cellular response to transforming growth factor beta stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of circulating fibrinogen levels IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of collagen biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of collagen biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of collagen fibril organization ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of negative regulation of cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of epithelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of extracellular matrix assembly NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-32 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of intestinal epithelial cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of matrix metallopeptidase secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of mesenchymal stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of metallopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of oxidative stress-induced cell death IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of type III interferon production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of voltage-gated potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of canonical Wnt signaling pathway involved in osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of metalloendopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of mitochondrial membrane permeability involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of triglyceride biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of DNA methylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of aorta morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of blood vessel remodeling NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of epithelium regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of regulation of membrane repolarization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of RISC complex IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space HDA PubMed 
located_in extracellular vesicle HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_029517.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC016831
    Related
    ENST00000385015.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    130877459..130877539 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    132194951..132195031 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)