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MIR29B1 microRNA 29b-1 [ Homo sapiens (human) ]

Gene ID: 407024, updated on 21-Dec-2019

Summary

Official Symbol
MIR29B1provided by HGNC
Official Full Name
microRNA 29b-1provided by HGNC
Primary source
HGNC:HGNC:31619
See related
Ensembl:ENSG00000283797 MIM:610783; miRBase:MI0000105
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
miR-29b; MIRN29B1; miRNA29B1; mir-29b-1
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Genomic context

See MIR29B1 in Genome Data Viewer
Location:
7q32.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (130877459..130877539, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (130562218..130562298, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375508 Neighboring gene zinc finger protein 131 pseudogene Neighboring gene long intergenic non-protein coding RNA, p53 induced transcript Neighboring gene microRNA 29a Neighboring gene long intergenic non-protein coding RNA 513 Neighboring gene RNA, U6 small nuclear 1010, pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Other Names

  • hsa-mir-29b-1

Gene Ontology Provided by GOA

Process Evidence Code Pubs
gene silencing by miRNA IDA
Inferred from Direct Assay
more info
PubMed 
gene silencing by miRNA IGI
Inferred from Genetic Interaction
more info
PubMed 
gene silencing by miRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
miRNA mediated inhibition of translation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of G1/S transition of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of NIK/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cellular response to transforming growth factor beta stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of circulating fibrinogen levels IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of collagen biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of collagen biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of collagen fibril organization ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of epithelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of extracellular matrix assembly IC
Inferred by Curator
more info
PubMed 
negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of intestinal epithelial cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of matrix metallopeptidase secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of mesenchymal stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of metallopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of oxidative stress-induced cell death IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of canonical Wnt signaling pathway involved in osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of metalloendopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of mitochondrial membrane permeability involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of triglyceride biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of DNA methylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of aorta morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of blood vessel remodeling NAS
Non-traceable Author Statement
more info
PubMed 
regulation of epithelium regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_029517.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC016831
    Related
    ENST00000385015.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    130877459..130877539 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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