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MIR27B microRNA 27b [ Homo sapiens (human) ]

Gene ID: 407019, updated on 24-Nov-2020

Summary

Official Symbol
MIR27Bprovided by HGNC
Official Full Name
microRNA 27bprovided by HGNC
Primary source
HGNC:HGNC:31614
See related
Ensembl:ENSG00000207864 MIM:610636; miRBase:MI0000440
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIR-27b; MIRN27B; miRNA27B
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Genomic context

See MIR27B in Genome Data Viewer
Location:
9q22.32
Exon count:
1
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (95085445..95085541)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (97847727..97847823)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene aminopeptidase O (putative) Neighboring gene microRNA 6081 Neighboring gene uncharacterized LOC107987102 Neighboring gene microRNA 3074 Neighboring gene microRNA 24-1 Neighboring gene microRNA 23b Neighboring gene FA complementation group C

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Other Names

  • hsa-mir-27b

Gene Ontology Provided by GOA

Process Evidence Code Pubs
NIK/NF-kappaB signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to vascular endothelial growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to vascular endothelial growth factor stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
cholesterol homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
gene silencing by miRNA IDA
Inferred from Direct Assay
more info
PubMed 
gene silencing by miRNA IEA
Inferred from Electronic Annotation
more info
 
gene silencing by miRNA IGI
Inferred from Genetic Interaction
more info
PubMed 
gene silencing by miRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
miRNA mediated inhibition of translation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of I-kappaB phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of NIK/NF-kappaB signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of cell adhesion molecule production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cholesterol efflux IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-1 beta production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of lipid binding IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of low-density lipoprotein particle clearance IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of low-density lipoprotein particle receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of monooxygenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of nitric-oxide synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of receptor-mediated endocytosis involved in cholesterol transport IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of tumor necrosis factor-mediated signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell adhesion involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration involved in sprouting angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell proliferation in bone marrow IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of intrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of lung blood pressure ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of pulmonary blood vessel remodeling ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vascular associated smooth muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cholesterol esterification IDA
Inferred from Direct Assay
more info
PubMed 
regulation of superoxide metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_029665.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AL354893
    Related
    ENST00000385129.3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    95085445..95085541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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