Format

Send to:

Choose Destination

MIR26A1 microRNA 26a-1 [ Homo sapiens (human) ]

Gene ID: 407015, updated on 1-Jun-2020

Summary

Official Symbol
MIR26A1provided by HGNC
Official Full Name
microRNA 26a-1provided by HGNC
Primary source
HGNC:HGNC:31610
See related
Ensembl:ENSG00000199075 MIM:612151; miRBase:MI0000083
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIR26A; MIRN26A1; mir-26a-1
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Genomic context

See MIR26A1 in Genome Data Viewer
Location:
3p22.2
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (37969404..37969480)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (38010895..38010971)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene integrin subunit alpha 9 Neighboring gene ITGA9 antisense RNA 1 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 4 pseudogene 3 Neighboring gene CTD small phosphatase like Neighboring gene HNF1 motif-containing MPRA enhancer 248 Neighboring gene Sharpr-MPRA regulatory region 7921 Neighboring gene villin like Neighboring gene phospholipase C delta 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Other Names

  • hsa-mir-26a-1

Gene Ontology Provided by GOA

Function Evidence Code Pubs
mRNA binding involved in posttranscriptional gene silencing IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
central nervous system myelin maintenance ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
gene silencing by miRNA IDA
Inferred from Direct Assay
more info
PubMed 
gene silencing by miRNA IEA
Inferred from Electronic Annotation
more info
 
negative regulation of BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell cycle G1/S phase transition IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell migration involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cholesterol efflux ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of cytokine production involved in inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of heart rate ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of interleukin-17 biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of interleukin-6 biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of interleukin-6 biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of interleukin-6 secretion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of interleukin-6-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of inward rectifier potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of neuroinflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of nitric-oxide synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of vascular smooth muscle cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of vascular associated smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vascular smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of atrial cardiac muscle cell membrane depolarization ISS
Inferred from Sequence or Structural Similarity
more info
 
transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
vascular endothelial growth factor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_029499.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC105752
    Related
    ENST00000362205.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    37969404..37969480
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center