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MIR222 microRNA 222 [ Homo sapiens (human) ]

Gene ID: 407007, updated on 3-Dec-2022

Summary

Official Symbol
MIR222provided by HGNC
Official Full Name
microRNA 222provided by HGNC
Primary source
HGNC:HGNC:31602
See related
Ensembl:ENSG00000207725 MIM:300569; miRBase:MI0000299; AllianceGenome:HGNC:31602
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIRN222; mir-222; miRNA222
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

See MIR222 in Genome Data Viewer
Location:
Xp11.3
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (45747015..45747124, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (45156474..45156583, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (45606421..45606530, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MFF pseudogene 3 Neighboring gene miR222/221 cluster host gene Neighboring gene microRNA 221 Neighboring gene long intergenic non-protein coding RNA 2595 Neighboring gene small nucleolar RNA SNORD77

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Other Names

  • hsa-mir-222

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in miRNA-mediated gene silencing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in miRNA-mediated gene silencing IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in miRNA-mediated gene silencing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in miRNA-mediated gene silencing by inhibition of translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation by host of viral genome replication ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of TRAIL-activated apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of TRAIL-activated apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cardiac muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell adhesion molecule production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of cytokine production involved in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of hematopoietic stem cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of inflammatory response IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of interleukin-21 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of leukocyte adhesion to vascular endothelial cell IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of Schwann cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of Schwann cell proliferation involved in axon regeneration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of axon regeneration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cardiac muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of epithelial cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of epithelial to mesenchymal transition IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of erythrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of vascular associated smooth muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_029636.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC234772
    Related
    ENST00000384992.3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    45747015..45747124 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    45156474..45156583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)