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MIR205 microRNA 205 [ Homo sapiens (human) ]

Gene ID: 406988, updated on 27-Nov-2022

Summary

Official Symbol
MIR205provided by HGNC
Official Full Name
microRNA 205provided by HGNC
Primary source
HGNC:HGNC:31583
See related
Ensembl:ENSG00000284485 MIM:613147; miRBase:MI0000285; AllianceGenome:HGNC:31583
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIRN205; mir-205
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

See MIR205 in Genome Data Viewer
Location:
1q32.2
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (209432133..209432242)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (208678941..208679050)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (209605478..209605587)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1696 Neighboring gene long intergenic non-protein coding RNA 1698 Neighboring gene MIR205 host gene Neighboring gene uncharacterized LOC105372898 Neighboring gene uncharacterized LOC105372899

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Other Names

  • hsa-mir-205

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in miRNA-mediated gene silencing HDA PubMed 
involved_in miRNA-mediated gene silencing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in miRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
 
involved_in miRNA-mediated gene silencing by inhibition of translation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of SMAD protein signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of negative regulation of SMAD protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of fibroblast growth factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of inflammatory response IC
Inferred by Curator
more info
PubMed 
acts_upstream_of negative regulation of osteoblast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of negative regulation of receptor-mediated endocytosis IC
Inferred by Curator
more info
PubMed 
involved_in negative regulation of vascular endothelial growth factor production HMP PubMed 
involved_in negative regulation of vascular endothelial growth factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of metalloendopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of aorta morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of RISC complex IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_029622.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AL035408
    Related
    ENST00000384891.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    209432133..209432242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    208678941..208679050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)