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MIR19B2 microRNA 19b-2 [ Homo sapiens (human) ]

Gene ID: 406981, updated on 10-Dec-2019

Summary

Official Symbol
MIR19B2provided by HGNC
Official Full Name
microRNA 19b-2provided by HGNC
Primary source
HGNC:HGNC:31576
See related
Ensembl:ENSG00000284107 MIM:300722; miRBase:MI0000075
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIRN19B2; miR-19b-2
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Genomic context

See MIR19B2 in Genome Data Viewer
Location:
Xq26.2
Exon count:
1
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (134169671..134169766, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (133303701..133303796, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene microRNA 363 Neighboring gene microRNA 92a-2 Neighboring gene microRNA 20b Neighboring gene microRNA 18b

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • Parkinsons Disease Pathway, organism-specific biosystem (from WikiPathways)
    Parkinsons Disease Pathway, organism-specific biosystemMost people with Parkinson's disease have idiopathic Parkinson's disease (having no specific known cause). A small proportion of cases, however, can be attributed to known genetic factors. Mutations ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Other Names

  • hsa-mir-19b-2

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cellular response to bacterial lipopeptide IDA
Inferred from Direct Assay
more info
PubMed 
cholesterol homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
gene silencing by miRNA IDA
Inferred from Direct Assay
more info
PubMed 
miRNA mediated inhibition of translation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of G2/M transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apolipoprotein A-I-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cardiac muscle cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell migration involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cholesterol efflux IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cholesterol efflux IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of coagulation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of inflammatory response to antigenic stimulus IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of interleukin-6 secretion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of matrix metallopeptidase secretion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of reverse cholesterol transport ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of apoptotic process involved in development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cardiac muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell growth involved in cardiac muscle cell development IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell growth involved in cardiac muscle cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of tyrosine phosphorylation of STAT protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of plasma lipoprotein particle levels ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
blood microparticle IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space HDA PubMed 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_029491.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC002407
    Related
    ENST00000385077.3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    134169671..134169766 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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