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MIR19B1 microRNA 19b-1 [ Homo sapiens (human) ]

Gene ID: 406980, updated on 23-Oct-2022

Summary

Official Symbol
MIR19B1provided by HGNC
Official Full Name
microRNA 19b-1provided by HGNC
Primary source
HGNC:HGNC:31575
See related
Ensembl:ENSG00000284375 MIM:609419; miRBase:MI0000074; AllianceGenome:HGNC:31575
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIRH1; MIR19B; MIRHG1; MIR17HG; C13orf25; MIRN19B1; miR-19b-1; miRNA19B1
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

See MIR19B1 in Genome Data Viewer
Location:
13q31.3
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (91351192..91351278)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (90553768..90553854)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (92003446..92003532)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene miR-17-92a-1 cluster host gene Neighboring gene microRNA 92a-1 Neighboring gene microRNA 19a Neighboring gene microRNA 20a Neighboring gene uncharacterized LOC124903189

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Other Names

  • MicroRNA-19b
  • Putative microRNA 17 host gene protein
  • Putative microRNA host gene 1 protein
  • hsa-mir-19b-1
  • miR-19b

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cellular response to bacterial lipopeptide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cholesterol homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in miRNA-mediated gene silencing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in miRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
 
involved_in miRNA-mediated gene silencing by inhibition of translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of G2/M transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of apolipoprotein A-I-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cardiac muscle cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell migration involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cholesterol efflux IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cholesterol efflux IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of coagulation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of inflammatory response to antigenic stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of matrix metallopeptidase secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of reverse cholesterol transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of apoptotic process involved in development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cardiac muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell growth involved in cardiac muscle cell development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cell growth involved in cardiac muscle cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of tyrosine phosphorylation of STAT protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of plasma lipoprotein particle levels ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of RISC complex IEA
Inferred from Electronic Annotation
more info
 
located_in blood microparticle IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space HDA PubMed 
located_in extracellular vesicle HDA PubMed 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032702.1 RefSeqGene

    Range
    8373..8459
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. NR_029490.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AL162375
    Related
    ENST00000384829.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    91351192..91351278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    90553768..90553854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)