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MIR19A microRNA 19a [ Homo sapiens (human) ]

Gene ID: 406979, updated on 25-Nov-2021

Summary

Official Symbol
MIR19Aprovided by HGNC
Official Full Name
microRNA 19aprovided by HGNC
Primary source
HGNC:HGNC:31574
See related
Ensembl:ENSG00000284204 MIM:609418; miRBase:MI0000073
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIRH1; MIRHG1; MIR17HG; MIRN19A; miR-19a; C13orf25; miRNA19A; hsa-mir-19a
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

See MIR19A in Genome Data Viewer
Location:
13q31.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (91350891..91350972)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (92003145..92003226)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene miR-17-92a-1 cluster host gene Neighboring gene microRNA 17 Neighboring gene microRNA 18a Neighboring gene microRNA 20a Neighboring gene microRNA 19b-1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Other Names

  • Putative microRNA 17 host gene protein
  • Putative microRNA host gene 1 protein

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in B cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to bacterial lipopeptide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in gene silencing by miRNA IDA
Inferred from Direct Assay
more info
PubMed 
involved_in gene silencing by miRNA IEA
Inferred from Electronic Annotation
more info
 
involved_in gene silencing by miRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cardiac muscle cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within negative regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of negative regulation of inflammatory response IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of negative regulation of inflammatory response to antigenic stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of interleukin-6 production IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of negative regulation of matrix metallopeptidase secretion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of matrix metallopeptidase secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of oxidative stress-induced cell death ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of toll-like receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of B cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell growth involved in cardiac muscle cell development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of tyrosine phosphorylation of STAT protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cardiac conduction IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032702.1 RefSeqGene

    Range
    8072..8153
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. NR_029489.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AL162375
    Related
    ENST00000384878.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    91350891..91350972
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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