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MIR199A1 microRNA 199a-1 [ Homo sapiens (human) ]

Gene ID: 406976, updated on 19-Jul-2021

Summary

Official Symbol
MIR199A1provided by HGNC
Official Full Name
microRNA 199a-1provided by HGNC
Primary source
HGNC:HGNC:31571
See related
Ensembl:ENSG00000207752 MIM:610719; miRBase:MI0000242
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIR-199-s; MIRN199A1; mir-199a-1
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

See MIR199A1 in Genome Data Viewer
Location:
19p13.2
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (10817426..10817496, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10928102..10928172, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene microRNA 638 Neighboring gene dynamin 2 Neighboring gene microRNA 4748 Neighboring gene microRNA 6793 Neighboring gene transmembrane p24 trafficking protein 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Other Names

  • hsa-mir-199a-1
  • miR-199a-3p

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell growth involved in cardiac muscle cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in gene silencing by miRNA IDA
Inferred from Direct Assay
more info
PubMed 
involved_in gene silencing by miRNA IEA
Inferred from Electronic Annotation
more info
 
involved_in gene silencing by miRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cardiac muscle cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cardiac muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell growth involved in cardiac muscle cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of negative regulation of cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of endoplasmic reticulum unfolded protein response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of hepatocyte growth factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of low-density lipoprotein particle clearance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of matrix metallopeptidase secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of metallopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of vascular endothelial growth factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of vascular endothelial growth factor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of TOR signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cardiac muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cardiac muscle hypertrophy in response to stress ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cardiac muscle tissue regeneration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell growth involved in cardiac muscle cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of connective tissue replacement ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of lung blood pressure ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of myoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of myoblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein kinase B signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in re-entry into mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT involved_in regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT involved_in regulation of cardiac muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT involved_in regulation of connective tissue replacement ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in extracellular space HDA PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_029586.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC007229
    Related
    ENST00000385019.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    10817426..10817496 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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