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MIR195 microRNA 195 [ Homo sapiens (human) ]

Gene ID: 406971, updated on 27-Nov-2022

Summary

Official Symbol
MIR195provided by HGNC
Official Full Name
microRNA 195provided by HGNC
Primary source
HGNC:HGNC:31566
See related
Ensembl:ENSG00000284112 MIM:610718; miRBase:MI0000489; AllianceGenome:HGNC:31566
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIRN195; mir-195; miRNA195
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

See MIR195 in Genome Data Viewer
Location:
17p13.1
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (7017615..7017701, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (6918215..6918301, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (6920934..6921020, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RNASEK-C17orf49 readthrough Neighboring gene ribonuclease K Neighboring gene chromosome 17 open reading frame 49 Neighboring gene mir-497-195 cluster host gene Neighboring gene microRNA 497 Neighboring gene BCL6B transcription repressor

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Other Names

  • hsa-mir-195

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA base-pairing translational repressor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cardiac muscle hypertrophy ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cardiac muscle tissue growth involved in heart morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell growth involved in cardiac muscle cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in miRNA-mediated gene silencing HDA PubMed 
involved_in miRNA-mediated gene silencing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in miRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of G2/M transition of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of fibroblast growth factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of glycogen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-1 beta production ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of interleukin-6 production ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of metalloendopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of neuroinflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of oxidative stress-induced cell death ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of tumor necrosis factor production ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of vascular endothelial growth factor production HMP PubMed 
involved_in negative regulation of vascular endothelial growth factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cardiac muscle cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of connective tissue replacement ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of glucosylceramidase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to ischemia IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
part_of RISC complex IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_029712.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC040977
    Related
    ENST00000385194.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    7017615..7017701 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    6918215..6918301 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)