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MIR181A2 microRNA 181a-2 [ Homo sapiens (human) ]

Gene ID: 406954, updated on 23-Oct-2022

Summary

Official Symbol
MIR181A2provided by HGNC
Official Full Name
microRNA 181a-2provided by HGNC
Primary source
HGNC:HGNC:31549
See related
Ensembl:ENSG00000207595 MIM:612743; miRBase:MI0000269; AllianceGenome:HGNC:31549
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIRN181A; MIRN181A2; mir-181a-2; hsa-mir-181a-2
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

See MIR181A2 in Genome Data Viewer
Location:
9q33.3
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (124692442..124692551)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (136890690..136890799)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (127454721..127454830)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene nuclear receptor subfamily 6 group A member 1 Neighboring gene RAN binding protein 1 pseudogene Neighboring gene RNA, 7SL, cytoplasmic 302, pseudogene Neighboring gene MIR181A2 host gene Neighboring gene microRNA 181b-2 Neighboring gene uncharacterized LOC124902269

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Other Names

  • hsa-mir-181a

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in miRNA-mediated gene silencing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in miRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
 
involved_in miRNA-mediated gene silencing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in miRNA-mediated gene silencing by inhibition of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of interleukin-1 alpha production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of interleukin-1 beta production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of interleukin-8 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of reactive oxygen species biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of endothelial cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of nitric oxide biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of p38MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of RISC complex IEA
Inferred from Electronic Annotation
more info
 
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space HDA PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_029611.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AL158075
    Related
    ENST00000384863.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    124692442..124692551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    136890690..136890799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)