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MIR17 microRNA 17 [ Homo sapiens (human) ]

Gene ID: 406952, updated on 28-Nov-2021

Summary

Official Symbol
MIR17provided by HGNC
Official Full Name
microRNA 17provided by HGNC
Primary source
HGNC:HGNC:31547
See related
Ensembl:ENSG00000284536 MIM:609416; miRBase:MI0000071
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIR91; MIRN17; MIRN91; miR-17; miRNA17; miRNA91; MIR17-5p; miR17-3p; hsa-mir-17
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

See MIR17 in Genome Data Viewer
Location:
13q31.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (91350605..91350688)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (92002859..92002942)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370313 Neighboring gene uncharacterized LOC105370314 Neighboring gene peptidylprolyl isomerase A pseudogene 23 Neighboring gene miR-17-92a-1 cluster host gene Neighboring gene microRNA 18a Neighboring gene microRNA 19a

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to lipopolysaccharide ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in gene silencing by miRNA HDA PubMed 
involved_in gene silencing by miRNA IDA
Inferred from Direct Assay
more info
PubMed 
involved_in gene silencing by miRNA IEA
Inferred from Electronic Annotation
more info
 
involved_in gene silencing by miRNA IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in miRNA-mediated gene silencing by inhibition of translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in miRNA-mediated gene silencing by inhibition of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of amyloid precursor protein biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of apoptosome assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cellular senescence ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of hydrogen peroxide-induced cell death ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of intrinsic apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of low-density lipoprotein particle clearance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of mitochondrial membrane permeability involved in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of receptor-mediated endocytosis involved in cholesterol transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of systemic arterial blood pressure ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of toll-like receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of vascular associated smooth muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of vascular endothelial growth factor production HMP PubMed 
involved_in outflow tract morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of blood pressure ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cardiac muscle cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cardiac muscle hypertrophy in response to stress ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of connective tissue replacement involved in inflammatory response wound healing ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cytokine production involved in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of fibroblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of hydrogen peroxide-mediated programmed cell death ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of metalloendopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of pulmonary blood vessel remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of smooth muscle hypertrophy ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of vascular associated smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of vascular associated smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vascular associated smooth muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032702.1 RefSeqGene

    Range
    7786..7869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. NR_029487.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AL162375
    Related
    ENST00000385012.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    91350605..91350688
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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