MIR146A microRNA 146a [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR146Aprovided by HGNC
Official Full Name: microRNA 146aprovided by HGNC
Primary source: HGNC:HGNC:31533
See related: Ensembl:ENSG00000283733 MIM:610566; miRBase:MI0000477
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MIRN146; MIRN146A; miR-146a; miRNA146A
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. Some of the targets of the encoded miRNA are the transcripts for tumor necrosis factor, interleukin 1 receptor-associated kinase 1, interleukin 1-beta, TNF receptor-associated factor 6, and complement factor H. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2015]
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Genomic context

Location:: 5q33.3

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
109.20210226	current	GRCh38.p13 (GCF_000001405.39)	5	NC_000005.10 (160485352..160485450)
105.20201022	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (159912359..159912457)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-146a-5p inhibits proliferation and promotes apoptosis of oral squamous cell carcinoma cells by regulating NF-kappaB signaling pathway.
Title: MiR-146a-5p inhibits proliferation and promotes apoptosis of oral squamous cell carcinoma cells by regulating NF-κB signaling pathway.
Absence of miRNA-146a Differentially Alters Microglia Function and Proteome.
Title: Absence of miRNA-146a Differentially Alters Microglia Function and Proteome.
Exposure to metal fumes and circulating miRNAs in Algerian welders.
Title: Exposure to metal fumes and circulating miRNAs in Algerian welders.
Investigation of the miRNA146a and miRNA155 gene expression levels in patients with multiple sclerosis.
Title: Investigation of the miRNA146a and miRNA155 gene expression levels in patients with multiple sclerosis.
miR-146a in Myasthenia Gravis Thymus Bridges Innate Immunity With Autoimmunity and Is Linked to Therapeutic Effects of Corticosteroids.
Title: miR-146a in Myasthenia Gravis Thymus Bridges Innate Immunity With Autoimmunity and Is Linked to Therapeutic Effects of Corticosteroids.
Circular RNA RSF1 promotes inflammatory and fibrotic phenotypes of irradiated hepatic stellate cell by modulating miR-146a-5p.
Title: Circular RNA RSF1 promotes inflammatory and fibrotic phenotypes of irradiated hepatic stellate cell by modulating miR-146a-5p.
Exosomes derived from chronic lymphocytic leukaemia cells transfer miR-146a to induce the transition of mesenchymal stromal cells into cancer-associated fibroblasts.
Title: Exosomes derived from chronic lymphocytic leukaemia cells transfer miR-146a to induce the transition of mesenchymal stromal cells into cancer-associated fibroblasts.
Reduced miR-146a Promotes REG3A Expression and Macrophage Migration in Polymyositis and Dermatomyositis.
Title: Reduced miR-146a Promotes REG3A Expression and Macrophage Migration in Polymyositis and Dermatomyositis.
Hepatitis A virus-induced hsa-miR-146a-5p attenuates IFN-beta signaling by targeting adaptor protein TRAF6.
Title: Hepatitis A virus-induced hsa-miR-146a-5p attenuates IFN-β signaling by targeting adaptor protein TRAF6.
Serum Exosomal miRNAs for Grading Hepatic Fibrosis Due to Schistosomiasis.
Title: Serum Exosomal miRNAs for Grading Hepatic Fibrosis Due to Schistosomiasis.

Submit: New GeneRIF Correction See all GeneRIFs (736)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
mRNA binding involved in posttranscriptional gene silencing	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
NIK/NF-kappaB signaling	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to amyloid-beta	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to cytokine stimulus	IDA Inferred from Direct Assay more info	PubMed
cellular response to glucose stimulus	IDA Inferred from Direct Assay more info	PubMed
cellular response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
cellular response to lipopolysaccharide	ISS Inferred from Sequence or Structural Similarity more info
cellular response to oxidised low-density lipoprotein particle stimulus	IDA Inferred from Direct Assay more info	PubMed
cellular response to virus	IDA Inferred from Direct Assay more info	PubMed
gene silencing by miRNA	IDA Inferred from Direct Assay more info	PubMed
gene silencing by miRNA	IEA Inferred from Electronic Annotation more info
gene silencing by miRNA	IMP Inferred from Mutant Phenotype more info	PubMed
interleukin-1-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
miRNA mediated inhibition of translation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of NIK/NF-kappaB signaling	IDA Inferred from Direct Assay more info	PubMed
negative regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of apoptotic DNA fragmentation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cell adhesion molecule production	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cell migration involved in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cell migration involved in sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of cellular extravasation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of chemokine (C-X-C motif) ligand 2 production	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cholesterol storage	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cytokine production involved in inflammatory response	IDA Inferred from Direct Assay more info	PubMed
negative regulation of endothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
negative regulation of glial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
negative regulation of interleukin-8 production	IDA Inferred from Direct Assay more info	PubMed
negative regulation of intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
negative regulation of leukocyte adhesion to vascular endothelial cell	IDA Inferred from Direct Assay more info	PubMed
negative regulation of matrix metallopeptidase secretion	IDA Inferred from Direct Assay more info	PubMed
negative regulation of membrane permeability	IDA Inferred from Direct Assay more info	PubMed
negative regulation of protein kinase B signaling	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of toll-like receptor 4 signaling pathway	IC Inferred by Curator more info	PubMed
negative regulation of tyrosine phosphorylation of STAT protein	IDA Inferred from Direct Assay more info	PubMed
negative regulation of vascular endothelial growth factor production	IDA Inferred from Direct Assay more info	PubMed
positive regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of apoptotic process in bone marrow cell	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell migration involved in sprouting angiogenesis	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell migration involved in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cellular senescence	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of fibroblast growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
positive regulation of neuron differentiation	IC Inferred by Curator more info	PubMed
regulation of stem cell differentiation	IDA Inferred from Direct Assay more info	PubMed
regulation of toll-like receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
extracellular exosome	IDA Inferred from Direct Assay more info	PubMed
extracellular exosome	ISS Inferred from Sequence or Structural Similarity more info
extracellular space	HDA more info	PubMed
extracellular space	IDA Inferred from Direct Assay more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.