MIR146A microRNA 146a [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR146Aprovided by HGNC
Official Full Name: microRNA 146aprovided by HGNC
Primary source: HGNC:HGNC:31533
See related: Ensembl:ENSG00000283733 MIM:610566; miRBase:MI0000477
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MIRN146; MIRN146A; miR-146a; miRNA146A
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. Some of the targets of the encoded miRNA are the transcripts for tumor necrosis factor, interleukin 1 receptor-associated kinase 1, interleukin 1-beta, TNF receptor-associated factor 6, and complement factor H. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2015]

Genomic context

Location:: 5q33.3

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
109.20190905	current	GRCh38.p13 (GCF_000001405.39)	5	NC_000005.10 (160485352..160485450)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (159912359..159912457)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

evaluated miRNA146a expression in follicular thyroid carcinoma, surgically removed from 35 patients; overall quantity of miRNA146a was reduced in follicular thyroid carcinoma tissue, compared to healthy thyroid tissue; however, overexpression of miRNA146a in all the cases of neoplastic tissue from patients affected by minimally invasive follicular thyroid carcinoma, metastatic to other organs was observed
Title: The prognostic value of miRNA146a in follicular thyroid carcinoma.
Our results also suggested that miR-146a rs2910164 CC genotype may be predisposing factor for development lung fibrosis and more progressive form of SSc. Results from relative expression analysis of miR-146a demonstrated that changes in the level of this miRNA may have an impact on development and clinical course of SSc.
Title: Impact of alterations in X-linked IRAK1gene and miR-146a on susceptibility and clinical manifestations in patients with systemic sclerosis.
Polymorphisms of miR-146a rs2910164 locus is not an independent risk factor for rheumatoid arthritis
Title: [Association of polymorphisms of miR-146a rs2910164 locus with clinical features of rheumatoid arthritis].
There was no significant difference in the miR-146a expression rate between BD patients and controls.
Title: Determination of mir-155 and mir-146a expression rates and its association with expression level of TNF-α and CTLA4 genes in patients with Behcet's disease.
miR-146a rs2910164 and miR-196a-2 rs11614913 polymorphisms, were identified in ovarian cancer patients and controls.
Title: Identification of miR-146a and miR-196a-2 single nucleotide polymorphisms at patients with high-grade serous ovarian cancer.
CHOP was identified as a target of miR-146a, and increased miR-146a expression in lung cancer cells was suggested to be responsible for CHOP mRNA down-regulation. Animal models confirmed that abnormally expressed miR-146a in lung cancer cells does not affect growth, but rather alters chemotherapy sensitivity.
Title: miRNA 146a promotes chemotherapy resistance in lung cancer cells by targeting DNA damage inducible transcript 3 (CHOP).
The minor allele G of miR-27a was associated with a decreased risk of breast cancer (OR 0.24 [95% CI 0.14-0.42] p < 0.001). The miR-196a2 (rs11614913) was not related to breast cancer (p > 0.05). Conclusion Our data indicate that miR-146a (rs2910164) and miR-27a (rs895819) variants contribute to breast cancer.
Title: Effects of miR-27a, miR-196a2 and miR-146a polymorphisms on the risk of breast cancer.
the inflamma-miR-146a-5p can serve as a personalized predictor of clinical outcome in obese patients entering physical activity weight-reduction programs.
Title: Physical Activity Modulates the Overexpression of the Inflammatory miR-146a-5p in Obese Patients.
Results identified that miR-196a was up-regulated by estrogen in ER positive breast cancer (BC) cells and enriched in ER-positive BC tissues. miR-196a was involved in estrogen-induced BC cell proliferation, migration and invasion.
Title: Estrogen-induced miR-196a elevation promotes tumor growth and metastasis via targeting SPRED1 in breast cancer.
miR-146a is highly expressed in primary gastric tumor independent of H. pylori infection. It is highly expressed in the lower stages and lymph node-negative tumors. It might suggest the importance of upregulation and downregulation of this miRNA in the initiating/promoting and progressive steps of gastric tumorigenesis, respectively.
Title: miR-146a is deregulated in gastric cancer.

Submit: New GeneRIF Correction See all GeneRIFs (612)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from BioSystems

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Melatonin metabolism and effects, organism-specific biosystem (from WikiPathways)
Melatonin metabolism and effects, organism-specific biosystemMelatonin is an important regulator of circadian rythmus and influences also insulin secretion, immune function, retinal function and neuroprotection. The synthesis starts with the amino acid tryptop...
MicroRNAs in cancer, organism-specific biosystem (from KEGG)
MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
MicroRNAs in cancer, conserved biosystem (from KEGG)
MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
mRNA binding involved in posttranscriptional gene silencing	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
NIK/NF-kappaB signaling	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to amyloid-beta	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to cytokine stimulus	IDA Inferred from Direct Assay more info	PubMed
cellular response to glucose stimulus	IDA Inferred from Direct Assay more info	PubMed
cellular response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
cellular response to lipopolysaccharide	ISS Inferred from Sequence or Structural Similarity more info
cellular response to virus	IDA Inferred from Direct Assay more info	PubMed
gene silencing by miRNA	IDA Inferred from Direct Assay more info	PubMed
gene silencing by miRNA	IEA Inferred from Electronic Annotation more info
gene silencing by miRNA	IMP Inferred from Mutant Phenotype more info	PubMed
interleukin-1-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of NIK/NF-kappaB signaling	IDA Inferred from Direct Assay more info	PubMed
negative regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of apoptotic DNA fragmentation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cell migration involved in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cell migration involved in sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of endothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
negative regulation of glial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
negative regulation of leukocyte adhesion to vascular endothelial cell	IDA Inferred from Direct Assay more info	PubMed
negative regulation of tyrosine phosphorylation of STAT protein	IDA Inferred from Direct Assay more info	PubMed
negative regulation of vascular endothelial growth factor production	IDA Inferred from Direct Assay more info	PubMed
positive regulation of apoptotic process in bone marrow	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell migration involved in sprouting angiogenesis	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell migration involved in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cellular senescence	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of fibroblast growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
positive regulation of neuron differentiation	IC Inferred by Curator more info	PubMed
regulation of stem cell differentiation	IDA Inferred from Direct Assay more info	PubMed
regulation of toll-like receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
RISC complex	IEA Inferred from Electronic Annotation more info
cell	IEA Inferred from Electronic Annotation more info
extracellular exosome	IDA Inferred from Direct Assay more info	PubMed
extracellular exosome	ISS Inferred from Sequence or Structural Similarity more info
extracellular space	HDA more info	PubMed
extracellular space	IDA Inferred from Direct Assay more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.