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MIR146A microRNA 146a [ Homo sapiens (human) ]

Gene ID: 406938, updated on 11-Sep-2019

Summary

Official Symbol
MIR146Aprovided by HGNC
Official Full Name
microRNA 146aprovided by HGNC
Primary source
HGNC:HGNC:31533
See related
Ensembl:ENSG00000283733 MIM:610566; miRBase:MI0000477
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIRN146; MIRN146A; miR-146a; miRNA146A
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. Some of the targets of the encoded miRNA are the transcripts for tumor necrosis factor, interleukin 1 receptor-associated kinase 1, interleukin 1-beta, TNF receptor-associated factor 6, and complement factor H. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2015]

Genomic context

See MIR146A in Genome Data Viewer
Location:
5q33.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (160485352..160485450)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (159912359..159912457)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 10249 Neighboring gene MIR3142 host gene Neighboring gene microRNA 3142 Neighboring gene ATPase phospholipid transporting 10B (putative) Neighboring gene long intergenic non-protein coding RNA 2159

Genomic regions, transcripts, and products

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Melatonin metabolism and effects, organism-specific biosystem (from WikiPathways)
    Melatonin metabolism and effects, organism-specific biosystemMelatonin is an important regulator of circadian rythmus and influences also insulin secretion, immune function, retinal function and neuroprotection. The synthesis starts with the amino acid tryptop...
  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...

General gene information

Other Names

  • hsa-mir-146
  • hsa-mir-146a

Gene Ontology Provided by GOA

Function Evidence Code Pubs
mRNA binding involved in posttranscriptional gene silencing IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
NIK/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to amyloid-beta IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to cytokine stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to glucose stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to lipopolysaccharide ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to virus IDA
Inferred from Direct Assay
more info
PubMed 
gene silencing by miRNA IDA
Inferred from Direct Assay
more info
PubMed 
gene silencing by miRNA IEA
Inferred from Electronic Annotation
more info
 
gene silencing by miRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-1-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of NIK/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic DNA fragmentation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell migration involved in sprouting angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of glial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of leukocyte adhesion to vascular endothelial cell IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of tyrosine phosphorylation of STAT protein IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of vascular endothelial growth factor production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process in bone marrow ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cellular senescence ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of fibroblast growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neuron differentiation IC
Inferred by Curator
more info
PubMed 
regulation of stem cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of toll-like receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
RISC complex IEA
Inferred from Electronic Annotation
more info
 
cell IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular space HDA PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_029701.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC091842
    Related
    ENST00000385201.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    160485352..160485450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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