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MIR146A microRNA 146a [ Homo sapiens (human) ]

Gene ID: 406938, updated on 27-Nov-2022

Summary

Official Symbol
MIR146Aprovided by HGNC
Official Full Name
microRNA 146aprovided by HGNC
Primary source
HGNC:HGNC:31533
See related
Ensembl:ENSG00000283733 MIM:610566; miRBase:MI0000477; AllianceGenome:HGNC:31533
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIRN146; MIRN146A; miR-146a; miRNA146A
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. Some of the targets of the encoded miRNA are the transcripts for tumor necrosis factor, interleukin 1 receptor-associated kinase 1, interleukin 1-beta, TNF receptor-associated factor 6, and complement factor H. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2015]
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Genomic context

See MIR146A in Genome Data Viewer
Location:
5q33.3
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (160485352..160485450)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (161013850..161013948)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (159912359..159912457)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 10249 Neighboring gene MIR3142 host gene Neighboring gene microRNA 3142 Neighboring gene ATPase phospholipid transporting 10B (putative) Neighboring gene long intergenic non-protein coding RNA 2159

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Other Names

  • hsa-mir-146
  • hsa-mir-146a

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA base-pairing translational repressor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in NIK/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to amyloid-beta IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to cytokine stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to glucose stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to lipopolysaccharide ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to oxidised low-density lipoprotein particle stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to virus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in interleukin-1-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in miRNA-mediated gene silencing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in miRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
 
involved_in miRNA-mediated gene silencing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in miRNA-mediated gene silencing by inhibition of translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in miRNA-mediated gene silencing by mRNA destabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of NIK/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of SMAD protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic DNA fragmentation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell adhesion molecule production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell migration involved in sprouting angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of negative regulation of cellular extravasation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of chemokine (C-X-C motif) ligand 2 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of cholesterol storage IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cytokine production involved in inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of glial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of interleukin-8 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of leukocyte adhesion to vascular endothelial cell IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of matrix metallopeptidase secretion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of membrane permeability IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of protein kinase B signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of toll-like receptor 4 signaling pathway IC
Inferred by Curator
more info
PubMed 
involved_in negative regulation of tyrosine phosphorylation of STAT protein IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of vascular endothelial growth factor production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of positive regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of apoptotic process in bone marrow cell ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell migration involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cellular senescence ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of fibroblast growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuron differentiation IC
Inferred by Curator
more info
PubMed 
acts_upstream_of positive regulation of vascular associated smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of positive regulation of vascular associated smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of stem cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of toll-like receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of RISC complex IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular space HDA PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_029701.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC091842
    Related
    ENST00000385201.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    160485352..160485450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    161013850..161013948
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)