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MIR140 microRNA 140 [ Homo sapiens (human) ]

Gene ID: 406932, updated on 24-Jul-2022

Summary

Official Symbol
MIR140provided by HGNC
Official Full Name
microRNA 140provided by HGNC
Primary source
HGNC:HGNC:31527
See related
Ensembl:ENSG00000208017 MIM:611894; miRBase:MI0000456; AllianceGenome:HGNC:31527
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SEDN; MIRN140; mir-140; miRNA140
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

See MIR140 in Genome Data Viewer
Location:
16q22.1
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (69933081..69933180)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (75735661..75735760)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (69966984..69967083)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene NIN1 (RPN12) binding protein 1 homolog Neighboring gene non-POU domain containing, octamer-binding pseudogene 1 Neighboring gene WW domain containing E3 ubiquitin protein ligase 2 Neighboring gene PDXDC2P-NPIPB14P readthrough Neighboring gene C-type lectin domain family 18 member A Neighboring gene nuclear pore complex interacting protein family member B14, pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Other Names

  • hsa-mir-140

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cellular response to amyloid-beta IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in miRNA-mediated gene silencing HDA PubMed 
involved_in miRNA-mediated gene silencing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in miRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
 
involved_in miRNA-mediated gene silencing IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of cytokine production involved in inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of toll-like receptor 4 signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of toll-like receptor 4 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of vascular associated smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of vascular associated smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of vascular associated smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of vascular endothelial growth factor production HMP PubMed 
involved_in positive regulation of BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of vascular associated smooth muscle cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of RISC complex IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_029681.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC026468
    Related
    ENST00000385282.3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    69933081..69933180
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    75735661..75735760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)