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MIR138-1 microRNA 138-1 [ Homo sapiens (human) ]

Gene ID: 406929, updated on 6-Sep-2021

Summary

Official Symbol
MIR138-1provided by HGNC
Official Full Name
microRNA 138-1provided by HGNC
Primary source
HGNC:HGNC:31524
See related
Ensembl:ENSG00000207954 MIM:613394; miRBase:MI0000476
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIRN138-1; mir-138-1
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

See MIR138-1 in Genome Data Viewer
Location:
3p21.32
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (44114212..44114310)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (44155704..44155802)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986081 Neighboring gene RNA, U6 small nuclear 367, pseudogene Neighboring gene testis and ovary specific TOPAZ 1 Neighboring gene uncharacterized LOC105377055 Neighboring gene T cell activation inhibitor, mitochondrial

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Other Names

  • hsa-mir-138-1

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mRNA binding involved in posttranscriptional gene silencing IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in gene silencing by miRNA IDA
Inferred from Direct Assay
more info
PubMed 
involved_in gene silencing by miRNA IEA
Inferred from Electronic Annotation
more info
 
involved_in miRNA mediated inhibition of translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 
involved_in negative regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression IDA
Inferred from Direct Assay
more info
 
involved_in negative regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of nitric-oxide synthase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of osteoblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of p38MAPK cascade IDA
Inferred from Direct Assay
more info
 
involved_in negative regulation of phosphatidylinositol 3-kinase activity IDA
Inferred from Direct Assay
more info
 
involved_in negative regulation of protein K63-linked ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of response to cytokine stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of stress fiber assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of vascular associated smooth muscle cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in plasma membrane raft assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein kinase B signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_029700.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC006058
    Related
    ENST00000385219.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    44114212..44114310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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