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MIR133A1 microRNA 133a-1 [ Homo sapiens (human) ]

Gene ID: 406922, updated on 2-Mar-2021

Summary

Official Symbol
MIR133A1provided by HGNC
Official Full Name
microRNA 133a-1provided by HGNC
Primary source
HGNC:HGNC:31517
See related
Ensembl:ENSG00000283927 MIM:610254; miRBase:MI0000450
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIRN133A1; mir-133a-1
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

See MIR133A1 in Genome Data Viewer
Location:
18q11.2
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (21825698..21825785, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (19405659..19405746, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene MIB E3 ubiquitin protein ligase 1 Neighboring gene VISTA enhancer hs1650 Neighboring gene RNA, 7SL, cytoplasmic 233, pseudogene Neighboring gene MIR133A1 host gene Neighboring gene microRNA 1-2 Neighboring gene ribosomal protein L34 pseudogene 32

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Other Names

  • hsa-mir-133a-1

Gene Ontology Provided by GOA

Function Evidence Code Pubs
mRNA binding involved in posttranscriptional gene silencing IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular response to cytokine stimulus IDA
Inferred from Direct Assay
more info
PubMed 
gene silencing by miRNA IDA
Inferred from Direct Assay
more info
PubMed 
gene silencing by miRNA IEA
Inferred from Electronic Annotation
more info
 
gene silencing by miRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of G1/S transition of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cAMP-dependent protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cardiac muscle cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cardiac muscle hypertrophy ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of delayed rectifier potassium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of epidermal growth factor receptor signaling pathway involved in heart process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of hydrogen peroxide-induced cell death ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of low-density lipoprotein particle clearance IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of membrane repolarization during cardiac muscle cell action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of myoblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of vascular associated smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cardiocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell fate commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of myotube differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of membrane repolarization during ventricular cardiac muscle cell action potential ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of ventricular cardiac muscle cell membrane repolarization ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
extracellular space HDA PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_029675.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC103987
    Related
    ENST00000385052.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    21825698..21825785 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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