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MIR128-1 microRNA 128-1 [ Homo sapiens (human) ]

Gene ID: 406915, updated on 13-May-2022

Summary

Official Symbol
MIR128-1provided by HGNC
Official Full Name
microRNA 128-1provided by HGNC
Primary source
HGNC:HGNC:31510
See related
Ensembl:ENSG00000207654 MIM:611774; miRBase:MI0000447; AllianceGenome:HGNC:31510
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIR128A; MIRN128A; MIRN128-1; mir-128-1
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

See MIR128-1 in Genome Data Viewer
Location:
2q21.3
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (135665397..135665478)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (136105929..136106010)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (136422967..136423048)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene zinc finger RANBP2-type containing 3 Neighboring gene Sharpr-MPRA regulatory region 5980 Neighboring gene R3H domain containing 1 Neighboring gene uncharacterized LOC124907893 Neighboring gene RNA, U6 small nuclear 512, pseudogene Neighboring gene uncharacterized LOC107985946 Neighboring gene UBX domain protein 4 Neighboring gene LCT antisense RNA 1 Neighboring gene lactase

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Other Names

  • hsa-mir-128-1
  • hsa-mir-128a
  • microRNA 128a

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA base-pairing post-transcriptional repressor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA base-pairing post-transcriptional repressor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cholesterol homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in lipid homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in miRNA-mediated gene silencing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in miRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
 
involved_in miRNA-mediated gene silencing ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in miRNA-mediated gene silencing by inhibition of translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of negative regulation of cholesterol efflux IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cholesterol efflux IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of lipoprotein particle clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of lipoprotein transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of macrophage colony-stimulating factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of macrophage migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of microglial cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of neuroinflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular space HDA PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_029672.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC016742
    Related
    ENST00000384921.4

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    135665397..135665478
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    136105929..136106010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)