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MIR124-2 microRNA 124-2 [ Homo sapiens (human) ]

Gene ID: 406908, updated on 17-Sep-2024

Summary

Official Symbol
MIR124-2provided by HGNC
Official Full Name
microRNA 124-2provided by HGNC
Primary source
HGNC:HGNC:31503
See related
Ensembl:ENSG00000207816 miRBase:MI0000444; AllianceGenome:HGNC:31503
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIRN124-2; MIRN124A2; mir-124-2
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

See MIR124-2 in Genome Data Viewer
Location:
8q12.3
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (64379149..64379257)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (64804556..64804664)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (65291706..65291814)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1414 Neighboring gene uncharacterized LOC105375877 Neighboring gene NANOG hESC enhancer GRCh37_chr8:65281318-65281819 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:65282636-65283161 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:65283162-65283688 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:65283689-65284213 Neighboring gene NANOG hESC enhancer GRCh37_chr8:65285363-65285903 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:65289123-65289700 Neighboring gene cytochrome c oxidase subunit 6C pseudogene 8 Neighboring gene MIR124-2 host gene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:65322543-65323742 Neighboring gene cytochrome c oxidase subunit NDUFA4-like Neighboring gene uncharacterized LOC124900252 Neighboring gene BHLHE22 antisense RNA 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Other Names

  • hsa-mir-124-2
  • hsa-mir-124a-2
  • microRNA 124a-2

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in miRNA-mediated post-transcriptional gene silencing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of RISC complex IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_029669.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC013492
    Related
    ENST00000385081.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    64379149..64379257
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    64804556..64804664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)