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LYZ lysozyme [ Homo sapiens (human) ]

Gene ID: 4069, updated on 6-Oct-2024

Summary

Official Symbol
LYZprovided by HGNC
Official Full Name
lysozymeprovided by HGNC
Primary source
HGNC:HGNC:6740
See related
Ensembl:ENSG00000090382 MIM:153450; AllianceGenome:HGNC:6740
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LZM; LYZF1; AMYLD5
Summary
This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014]
Expression
Biased expression in stomach (RPKM 5710.8), salivary gland (RPKM 4398.2) and 8 other tissues See more
Orthologs
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Genomic context

See LYZ in Genome Data Viewer
Location:
12q15
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (69348381..69354234)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (69327311..69333169)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (69742161..69748014)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene cleavage and polyadenylation specific factor 6 Neighboring gene microRNA 1279 Neighboring gene C1GALT1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6649 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:69725950-69726664 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:69753267-69753870 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:69753871-69754472 Neighboring gene YEATS domain containing 4 Neighboring gene RNA, 7SL, cytoplasmic 804, pseudogene Neighboring gene Sharpr-MPRA regulatory regions 8384 and 8454 Neighboring gene ribosomal protein S26 pseudogene 45

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Familial visceral amyloidosis, Ostertag type
MedGen: C0268389 OMIM: 105200 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic.
EBI GWAS Catalog
Many sequence variants affecting diversity of adult human height.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify lysozyme (LYZ), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify lysozyme (LYZ), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify lysozyme (LYZ), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify lysozyme (LYZ), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Tat tat HIV-1 Tat downregulates the expression of lysozyme (LYZ) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables lysozyme activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables lysozyme activity TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
lysozyme C
Names
1,4-beta-N-acetylmuramidase C
c-type lysozyme
lysozyme F1
NP_000230.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008195.1 RefSeqGene

    Range
    5001..10880
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_768

mRNA and Protein(s)

  1. NM_000239.3NP_000230.1  lysozyme C precursor

    See identical proteins and their annotated locations for NP_000230.1

    Status: REVIEWED

    Source sequence(s)
    AC020656, AK130149, J03801
    Consensus CDS
    CCDS8989.1
    UniProtKB/Swiss-Prot
    P00695, P61626, Q13170, Q9UCF8
    UniProtKB/TrEMBL
    B2R4C5
    Related
    ENSP00000261267.2, ENST00000261267.7
    Conserved Domains (1) summary
    smart00263
    Location:19147
    LYZ1; Alpha-lactalbumin / lysozyme C

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    69348381..69354234
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    69327311..69333169
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)