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MIR101-1 microRNA 101-1 [ Homo sapiens (human) ]

Gene ID: 406893, updated on 5-Jan-2022

Summary

Official Symbol
MIR101-1provided by HGNC
Official Full Name
microRNA 101-1provided by HGNC
Primary source
HGNC:HGNC:31488
See related
Ensembl:ENSG00000199135 MIM:612511; miRBase:MI0000103
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIRN101-1; mir-101-1
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

See MIR101-1 in Genome Data Viewer
Location:
1p31.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (65058434..65058508, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (65524117..65524191, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Janus kinase 1 Neighboring gene RNA, U6 small nuclear 1176, pseudogene Neighboring gene microRNA 3671 Neighboring gene ribosomal protein S24 pseudogene Neighboring gene mitochondrial ribosomal protein S21 pseudogene 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Other Names

  • hsa-mir-101-1

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA binding involved in posttranscriptional gene silencing IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in gene silencing by miRNA IDA
Inferred from Direct Assay
more info
PubMed 
involved_in gene silencing by miRNA IEA
Inferred from Electronic Annotation
more info
 
involved_in miRNA-mediated gene silencing by inhibition of translation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of amyloid precursor protein biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of negative regulation of blood vessel endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell adhesion molecule production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of cell adhesion molecule production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of interleukin-1 beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of necroptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell migration involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of positive regulation of endothelial cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to interleukin-1 ISS
Inferred from Sequence or Structural Similarity
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_029516.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AL357078
    Related
    ENST00000362265.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    65058434..65058508 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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