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Mpig6b megakaryocyte and platelet inhibitory receptor G6b [ Rattus norvegicus (Norway rat) ]

Gene ID: 406865, updated on 11-Apr-2024

Summary

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Official Symbol
Mpig6bprovided by RGD
Official Full Name
megakaryocyte and platelet inhibitory receptor G6bprovided by RGD
Primary source
RGD:1303269
See related
Ensembl:ENSRNOG00000026936 AllianceGenome:RGD:1303269
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
G6b; Ng31; C6orf25
Summary
Predicted to enable heparin binding activity. Predicted to be involved in several processes, including blood coagulation; integrin-mediated signaling pathway; and myeloid cell differentiation. Predicted to be located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and nucleoplasm. Predicted to be active in plasma membrane. Orthologous to human MPIG6B (megakaryocyte and platelet inhibitory receptor G6b). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 9.5), Testes (RPKM 5.2) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
20p12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (3761832..3765679)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (3757396..3761024)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (5054419..5056655, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene lymphocyte antigen 6 family member G6D Neighboring gene lymphocyte antigen 6 family member G6E Neighboring gene lymphocyte antigen 6 family member G6C Neighboring gene DDAH family member 2, ADMA-independent Neighboring gene chloride intracellular channel 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Novel G6B gene variant causes familial autosomal recessive thrombocytopenia and anemia. Melhem M, et al. Eur J Haematol, 2017 Mar. PMID 27743390
  2. G6b, a novel immunoglobulin superfamily member encoded in the human major histocompatibility complex, interacts with SHP-1 and SHP-2. de Vet EC, et al. J Biol Chem, 2001 Nov 9. PMID 11544253
  3. G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2. Mori J, et al. J Biol Chem, 2008 Dec 19. PMID 18955485, Free PMC Article
  4. Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function. Mazharian A, et al. Blood, 2013 May 16. PMID 23509158, Free PMC Article
  5. Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function. Mazharian A, et al. Sci Signal, 2012 Oct 30. PMID 23112346, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables heparin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in blood coagulation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within blood coagulation ISO
Inferred from Sequence Orthology
more info
  
involved_in blood coagulation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in erythrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in integrin-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in megakaryocyte development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in megakaryocyte development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within megakaryocyte development ISO
Inferred from Sequence Orthology
more info
  
involved_in megakaryocyte development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in megakaryocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in megakaryocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in platelet formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in platelet formation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within platelet formation ISO
Inferred from Sequence Orthology
more info
  
involved_in platelet formation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
megakaryocyte and platelet inhibitory receptor G6b
Names
immunoreceptor tyrosine-based inhibitory motif (ITIM) containing platelet receptor
protein G6b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412137.2 → NP_001399066.1  megakaryocyte and platelet inhibitory receptor G6b precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/TrEMBL
    A0A096MKA0
    Related
    ENSRNOP00000068435.1, ENSRNOT00000076375.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    3761832..3765679
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279382.1 → XP_063135452.1  megakaryocyte and platelet inhibitory receptor G6b isoform X1

    UniProtKB/TrEMBL
    A0A096MJK2

RNA

  1. XR_005497318.2 RNA Sequence

  2. XR_005497316.2 RNA Sequence

  3. XR_005497317.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001003976.1: Suppressed sequence

    Description
    NM_001003976.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6MG59.1 GenPept UniProtKB/Swiss-Prot:Q6MG59

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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