Format

Send to:

Choose Destination

msh2 mutS homolog 2 (E. coli) [ Danio rerio (zebrafish) ]

Gene ID: 406845, updated on 14-Feb-2019

Summary

Official Symbol
msh2provided by ZNC
Official Full Name
mutS homolog 2 (E. coli)provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2932
See related
Ensembl:ENSDARG00000018022
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
Also known as
zgc:55333; wu:fc06b02; wu:fc13e09
Orthologs

Genomic context

See msh2 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (24906108..24928497, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (24784889..24807278, complement)
103 previous assembly Zv9 (GCF_000002035.4) 12 NC_007123.5 (26412448..26434837, complement)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene forkhead box N2b Neighboring gene F-box protein 11b Neighboring gene calmodulin 2b, (phosphorylase kinase, delta) Neighboring gene suppressor of cytokine signaling 5a

Genomic regions, transcripts, and products

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-dependent ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to four-way junction DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to guanine/thymine mispair binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
guanine/thymine mispair binding IDA
Inferred from Direct Assay
more info
PubMed 
guanine/thymine mispair binding IGI
Inferred from Genetic Interaction
more info
PubMed 
mismatched DNA binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to single thymine insertion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
DNA repair IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intra-S DNA damage checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
maintenance of DNA repeat elements IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
maintenance of DNA repeat elements IMP
Inferred from Mutant Phenotype
more info
PubMed 
mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mismatch repair IEA
Inferred from Electronic Annotation
more info
 
mismatch repair ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of DNA recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postreplication repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to UV-B IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to X-ray IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
MutSalpha complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MutSbeta complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mismatch repair complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mismatch repair complex IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DNA mismatch repair protein Msh2
Names
mismatch repair protein Msh2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213524.1NP_998689.1  DNA mismatch repair protein Msh2

    See identical proteins and their annotated locations for NP_998689.1

    Status: PROVISIONAL

    Source sequence(s)
    BC044370
    UniProtKB/TrEMBL
    Q803R6
    Related
    ENSDARP00000027768.6, ENSDART00000002465.7
    Conserved Domains (6) summary
    cd03285
    Location:633852
    ABC_MSH2_euk; ATP-binding cassette domain of eukaryotic MutS2 homolog
    COG0249
    Location:23911
    MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
    pfam01624
    Location:17129
    MutS_I; MutS domain I
    pfam05188
    Location:158283
    MutS_II; MutS domain II
    pfam05190
    Location:473569
    MutS_IV; MutS family domain IV
    pfam05192
    Location:305423
    MutS_III; MutS domain III

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    24906108..24928497 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394844.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    243375..265764 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center