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pitrm1 pitrilysin metallopeptidase 1 [ Danio rerio (zebrafish) ]

Gene ID: 406808, updated on 9-Sep-2025
Official Symbol
pitrm1provided by ZNC
Official Full Name
pitrilysin metallopeptidase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2876
See related
Ensembl:ENSDARG00000038563 AllianceGenome:ZFIN:ZDB-GENE-040426-2876
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:55469; wu:fa03d09
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 30. Orthologous to human PITRM1 (pitrilysin metallopeptidase 1). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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See pitrm1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 2 NC_133177.1 (51362344..51394214)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 2 NC_007113.7 (48089057..48119264)

Chromosome 2 - NC_133177.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC141378861 Neighboring gene uncharacterized LOC141378791 Neighboring gene uncharacterized LOC141378880 Neighboring gene Kruppel like factor 6b Neighboring gene phosphofructokinase, platelet b Neighboring gene transfer RNA isoleucine (anticodon AAU)

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Genome-wide identification of molecular pathways and biomarkers in response to arsenic exposure in zebrafish liver. Xu H, et al. PLoS One, 2013. PMID 23922661, Free PMC Article
  2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
presequence protease, mitochondrial
Names
pitrilysin metalloproteinase 1
NP_998652.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213487.1 → NP_998652.1  presequence protease, mitochondrial precursor

    See identical proteins and their annotated locations for NP_998652.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045351
    UniProtKB/Swiss-Prot
    Q7ZVZ6
    UniProtKB/TrEMBL
    B2GRL2
    Related
    ENSDARP00000056293.4, ENSDART00000056294.5
    Conserved Domains (4) summary
    COG1026
    Location:40 → 1018
    Cym1; Zn-dependent peptidase, M16 (insulinase) family [Posttranslational modification, protein turnover, chaperones]
    pfam00675
    Location:91 → 172
    Peptidase_M16; Insulinase (Peptidase family M16)
    pfam05193
    Location:240 → 427
    Peptidase_M16_C; Peptidase M16 inactive domain
    pfam08367
    Location:501 → 743
    M16C_assoc; Peptidase M16C associated

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133177.1 Reference GRCz12tu Primary Assembly

    Range
    51362344..51394214
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7ZVZ6.1 GenPept UniProtKB/Swiss-Prot:Q7ZVZ6

Gene LinkOut

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