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acp5a acid phosphatase 5a, tartrate resistant [ Danio rerio (zebrafish) ]

Gene ID: 406801, updated on 9-Sep-2025
Official Symbol
acp5aprovided by ZNC
Official Full Name
acid phosphatase 5a, tartrate resistantprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2864
See related
Ensembl:ENSDARG00000019763 AllianceGenome:ZFIN:ZDB-GENE-040426-2864
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
TRAP; acp5; sb:cb576; zgc:63825; wu:fb19f01; wu:fb30b03; wu:fi14e01; wu:fj66f03
Summary
Predicted to enable acid phosphatase activity; ferric iron binding activity; and ferrous iron binding activity. Predicted to be involved in bone resorption. Is expressed in several structures, including cranium; fin; hematopoietic system; scale; and yolk syncytial layer. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia. Orthologous to human ACP5 (acid phosphatase 5, tartrate resistant). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
human mouse all
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See acp5a in Genome Data Viewer
Location:
chromosome: 6
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 6 NC_133181.1 (9291837..9299338, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 6 NC_007117.7 (8355229..8362506, complement)

Chromosome 6 - NC_133181.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 44 member 2 (CTL2 blood group) Neighboring gene uncharacterized LOC137490182 Neighboring gene glutaryl-CoA dehydrogenase a Neighboring gene interleukin enhancer binding factor 3a Neighboring gene uncharacterized LOC137487446 Neighboring gene prostaglandin E receptor 1a (subtype EP1)

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. An ancestral mycobacterial effector promotes dissemination of infection. Saelens JW, et al. Cell, 2022 Nov 23. PMID 36356582, Free PMC Article
  2. The zebrafish genome in context: ohnologs gone missing. Postlethwait JH. J Exp Zool B Mol Dev Evol, 2007 Sep 15. PMID 17068775
  3. Evaluation of Dexamethasone-Induced Osteoporosis In Vivo Using Zebrafish Scales. Chaichit S, et al. Pharmaceuticals (Basel), 2021 Jun 3. PMID 34205111, Free PMC Article
  4. Osteoclast-like Cells in Early Zebrafish Embryos. Sharif F, et al. Cell J, 2014 Summer. PMID 24567948, Free PMC Article
  5. Anti-osteoporosis effects of Anemarrhenae Rhizoma / Phellodendri Chinensis Cortex herb pair and its major active components in diabetic rats and zebrafish. Xu P, et al. J Ethnopharmacol, 2022 Jul 15. PMID 35398497

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables acid phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acid phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables ferric iron binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferrous iron binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in bone resorption IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
tartrate-resistant acid phosphatase type 5a
Names
acid phosphatase 5, tartrate resistant
tartrate-resistant acid phosphatase
NP_999938.1
XP_005165782.1
XP_005165783.1
XP_068077793.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214773.1 → NP_999938.1  tartrate-resistant acid phosphatase type 5a precursor

    See identical proteins and their annotated locations for NP_999938.1

    Status: PROVISIONAL

    Source sequence(s)
    BC055256
    UniProtKB/TrEMBL
    A0A8M1PK00, Q7SXT1
    Related
    ENSDARP00000017532.8, ENSDART00000004716.10
    Conserved Domains (2) summary
    cd07378
    Location:36 → 319
    MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
    pfam00149
    Location:36 → 251
    Metallophos; Calcineurin-like phosphoesterase

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133181.1 Reference GRCz12tu Primary Assembly

    Range
    9291837..9299338 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068221692.2 → XP_068077793.1  tartrate-resistant acid phosphatase type 5a isoform X2

    UniProtKB/TrEMBL
    A0AB32TUZ0

  2. XM_005165726.6 → XP_005165783.1  tartrate-resistant acid phosphatase type 5a isoform X1

    See identical proteins and their annotated locations for XP_005165783.1

    UniProtKB/TrEMBL
    A0A8M1PK00, Q7SXT1
    Conserved Domains (2) summary
    cd07378
    Location:36 → 319
    MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
    pfam00149
    Location:36 → 251
    Metallophos; Calcineurin-like phosphoesterase

  3. XM_005165725.6 → XP_005165782.1  tartrate-resistant acid phosphatase type 5a isoform X1

    See identical proteins and their annotated locations for XP_005165782.1

    UniProtKB/TrEMBL
    A0A8M1PK00, Q7SXT1
    Conserved Domains (2) summary
    cd07378
    Location:36 → 319
    MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
    pfam00149
    Location:36 → 251
    Metallophos; Calcineurin-like phosphoesterase
Nucleotide Protein Strain
Heading Accession and Version

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