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hk1 hexokinase 1 [ Danio rerio (zebrafish) ]

Gene ID: 406791, updated on 19-May-2025
Official Symbol
hk1provided by ZNC
Official Full Name
hexokinase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2848
See related
Ensembl:ENSDARG00000039452 AllianceGenome:ZFIN:ZDB-GENE-040426-2848
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:55790; zgc:77618; im:7148527; wu:fc09d08; wu:fc16e02; wu:fc21e02; wu:fq14b11
Summary
Predicted to enable fructokinase activity; glucokinase activity; and mannokinase activity. Predicted to be involved in several processes, including glucose 6-phosphate metabolic process; glycolytic process; and intracellular glucose homeostasis. Predicted to act upstream of or within several processes, including inflammatory response; innate immune response; and phosphorylation. Predicted to be located in mitochondrial outer membrane. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including cardiovascular system; mesoderm; musculature system; nervous system; and neural tube. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4G; anemia (multiple); hematologic cancer (multiple); obesity; and retinitis pigmentosa. Orthologous to human HK1 (hexokinase 1). [provided by Alliance of Genome Resources, May 2025]
Orthologs
human mouse all
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See hk1 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 13 NC_133188.1 (26137458..26165787, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 13 NC_007124.7 (22972888..23007813, complement)

Chromosome 13 - NC_133188.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC141377181 Neighboring gene tetraspanin 15 Neighboring gene tachykinin receptor 2 Neighboring gene uncharacterized LOC141377176 Neighboring gene hexokinase domain containing 1 Neighboring gene SUV3-like helicase

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Automated in vivo screen in zebrafish identifies Clotrimazole as targeting a metabolic vulnerability in a melanoma model. Precazzini F, et al. Dev Biol, 2020 Jan 15. PMID 30998907
  2. The effects of Roundup® in embryo development and energy metabolism of the zebrafish (Danio rerio). Panetto OS, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2019 Aug. PMID 30981909
  3. Effects of short term lead exposure on gut microbiota and hepatic metabolism in adult zebrafish. Xia J, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2018 Jul. PMID 29574035
  4. The hexokinase gene family in the zebrafish: structure, expression, functional and phylogenetic analysis. González-Alvarez R, et al. Comp Biochem Physiol B Biochem Mol Biol, 2009 Feb. PMID 19087890
  5. Conserved glucokinase regulation in zebrafish confirms therapeutic utility for pharmacologic modulation in diabetes. Schmitner N, et al. Commun Biol, 2024 Nov 23. PMID 39580550, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables D-glucose binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables fructokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hexokinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, alcohol group as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glucose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glycolytic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intracellular glucose homeostasis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
hexokinase-1
Names
DrHXK1
NP_998417.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213252.1 → NP_998417.1  hexokinase-1

    See identical proteins and their annotated locations for NP_998417.1

    Status: PROVISIONAL

    Source sequence(s)
    BC048065
    UniProtKB/TrEMBL
    Q7ZUM3
    Related
    ENSDARP00000057637.2, ENSDART00000057638.4
    Conserved Domains (3) summary
    PTZ00107
    Location:462 → 907
    PTZ00107; hexokinase; Provisional
    pfam00349
    Location:469 → 667
    Hexokinase_1; Hexokinase
    pfam03727
    Location:673 → 907
    Hexokinase_2; Hexokinase

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133188.1 Reference GRCz12tu Primary Assembly

    Range
    26137458..26165787 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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