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hdac8 histone deacetylase 8 [ Danio rerio (zebrafish) ]

Gene ID: 406740, updated on 5-Jul-2025
Official Symbol
hdac8provided by ZNC
Official Full Name
histone deacetylase 8provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2772
See related
Ensembl:ENSDARG00000003021 AllianceGenome:ZFIN:ZDB-GENE-040426-2772
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:66196; wu:fd19a02
Summary
Predicted to enable histone deacetylase activity and histone decrotonylase activity. Acts upstream of or within central nervous system development and neuron cellular homeostasis. Predicted to be located in several cellular components, including chromosome; nucleus; and plasma membrane. Predicted to be part of histone deacetylase complex. Is expressed in several structures, including brain; fin bud; gut; muscle; and oocyte. Used to study Cornelia de Lange syndrome. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 5 and Wilson-Turner syndrome. Orthologous to human HDAC8 (histone deacetylase 8). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
human mouse all
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See hdac8 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 7 NC_133182.1 (53500769..53557005, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 7 NC_007118.7 (51656099..51709994, complement)

Chromosome 7 - NC_133182.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S4 X-linked Neighboring gene Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 Neighboring gene phosphorylase kinase, alpha 1a (muscle) Neighboring gene liver-expressed antimicrobial peptide 2

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Modeling Cornelia de Lange syndrome in vitro and in vivo reveals a role for cohesin complex in neuronal survival and differentiation. Bottai D, et al. Hum Mol Genet, 2019 Jan 1. PMID 30239720
  2. Histone Deacetylases Cooperate with NF-κB to Support the Immediate Migratory Response after Zebrafish Pronephros Injury. Zhuang M, et al. Int J Mol Sci, 2022 Aug 24. PMID 36076983, Free PMC Article
  3. X-linked myotubular myopathy is associated with epigenetic alterations and is ameliorated by HDAC inhibition. Volpatti JR, et al. Acta Neuropathol, 2022 Sep. PMID 35844027, Free PMC Article
  4. HDAC8 regulates canonical Wnt pathway to promote differentiation in skeletal muscles. Ferrari L, et al. J Cell Physiol, 2019 May. PMID 30246374
  5. HDAC8: A Promising Therapeutic Target for Acute Myeloid Leukemia. Spreafico M, et al. Front Cell Dev Biol, 2020. PMID 33015043, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Histone Deacetylases Cooperate with NF-kappaB to Support the Immediate Migratory Response after Zebrafish Pronephros Injury.
    Title: Histone Deacetylases Cooperate with NF-κB to Support the Immediate Migratory Response after Zebrafish Pronephros Injury.
  2. We have shown for the first time that HDAC8 is expressed in human and zebrafish skeletal muscles
    Title: HDAC8 regulates canonical Wnt pathway to promote differentiation in skeletal muscles.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone deacetylase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone deacetylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone deacetylase activity, hydrolytic mechanism IEA
Inferred from Electronic Annotation
more info
  
enables histone decrotonylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein decrotonylase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein lysine deacetylase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within central nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuron cellular homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of histone deacetylase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
histone deacetylase 8
Names
HD8
protein deacetylase HDAC8
protein decrotonylase HDAC8
NP_998596.1
XP_005166564.1
XP_073762471.1
XP_073762472.1
XP_073762473.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213431.1 → NP_998596.1  histone deacetylase 8

    See identical proteins and their annotated locations for NP_998596.1

    Status: PROVISIONAL

    Source sequence(s)
    BC055541
    UniProtKB/Swiss-Prot
    Q7SXM0
    Related
    ENSDARP00000017858.4, ENSDART00000009184.6
    Conserved Domains (1) summary
    cd10000
    Location:17 → 378
    HDAC8; Histone deacetylase 8 (HDAC8)

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133182.1 Reference GRCz12tu Primary Assembly

    Range
    53500769..53557005 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073906371.1 → XP_073762472.1  histone deacetylase 8 isoform X2

  2. XM_005166507.5 → XP_005166564.1  histone deacetylase 8 isoform X3

    UniProtKB/TrEMBL
    A0A8M2BE34
    Conserved Domains (1) summary
    cl17011
    Location:1 → 311
    Arginase_HDAC; Arginase-like and histone-like hydrolases

  3. XM_073906370.1 → XP_073762471.1  histone deacetylase 8 isoform X1

  4. XM_073906372.1 → XP_073762473.1  histone deacetylase 8 isoform X3

    UniProtKB/TrEMBL
    A0A8M2BE34

RNA

  1. XR_012382362.1 RNA Sequence

  2. XR_012382363.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7SXM0.1 GenPept UniProtKB/Swiss-Prot:Q7SXM0

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