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pdha1a pyruvate dehydrogenase E1 subunit alpha 1a [ Danio rerio (zebrafish) ]

Gene ID: 406702, updated on 11-Jun-2025
Official Symbol
pdha1aprovided by ZNC
Official Full Name
pyruvate dehydrogenase E1 subunit alpha 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2719
See related
Ensembl:ENSDARG00000012387 AllianceGenome:ZFIN:ZDB-GENE-040426-2719
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
pdha1; zgc:73271; zgc:86692; im:6895726; wu:fd18b01; wu:fo96f03
Summary
Predicted to enable pyruvate dehydrogenase (acetyl-transferring) activity. Predicted to be involved in pyruvate decarboxylation to acetyl-CoA. Predicted to act upstream of or within glucose metabolic process. Predicted to be located in intracellular membrane-bounded organelle. Is expressed in several structures, including adaxial cell; alar plate midbrain region; heart tube; musculature system; and pronephric duct. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1). [provided by Alliance of Genome Resources, Jun 2025]
Orthologs
all
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See pdha1a in Genome Data Viewer
Location:
chromosome: 5
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 5 NC_133180.1 (24687330..24700742, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 5 NC_007116.7 (24031314..24044724, complement)

Chromosome 5 - NC_133180.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 1A X-linked a Neighboring gene ribosomal protein S6 kinase a, polypeptide 3a Neighboring gene CTD nuclear envelope phosphatase 1a Neighboring gene GABA(A) receptor-associated protein a

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Relative comparison of strobilurin fungicides at environmental levels: Focus on mitochondrial function and larval activity in early staged zebrafish (Danio rerio). Li XY, et al. Toxicology, 2021 Mar 30. PMID 33548355
  2. Metabolic modulation regulates cardiac wall morphogenesis in zebrafish. Fukuda R, et al. Elife, 2019 Dec 23. PMID 31868165, Free PMC Article
  3. Low Phosphorus Causes Hepatic Energy Metabolism Disorder Through Dynamin-Related Protein 1-Mediated Mitochondrial Fission in Fish. Lin J, et al. J Nutr, 2025 Jan. PMID 39491675
  4. HIF signaling and overall gene expression changes during hypoxia and prolonged exercise differ considerably. Kopp R, et al. Physiol Genomics, 2011 May 13. PMID 21343420
  5. Responses of the Proteome and Metabolome in Livers of Zebrafish Exposed Chronically to Environmentally Relevant Concentrations of Microcystin-LR. Chen L, et al. Environ Sci Technol, 2017 Jan 3. PMID 28005350

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables pyruvate dehydrogenase (acetyl-transferring) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyruvate dehydrogenase (acetyl-transferring) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within glucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyruvate decarboxylation to acetyl-CoA IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within pyruvate decarboxylation to acetyl-CoA IEA
Inferred from Electronic Annotation
more info
  
involved_in pyruvate decarboxylation to acetyl-CoA IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
pyruvate dehydrogenase E1 subunit alpha 1a
Names
pyruvate dehydrogenase (lipoamide) alpha 1
pyruvate dehydrogenase (lipoamide) alpha 1a
pyruvate dehydrogenase E1 alpha 1 subunit a
NP_998558.1
XP_005165191.1
XP_073806209.1
XP_073806210.1
XP_073806211.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213393.1 → NP_998558.1  pyruvate dehydrogenase E1 subunit alpha 1a

    See identical proteins and their annotated locations for NP_998558.1

    Status: PROVISIONAL

    Source sequence(s)
    BC071373
    UniProtKB/TrEMBL
    Q6IQN1, Q6P948
    Related
    ENSDARP00000024338.5, ENSDART00000023784.7
    Conserved Domains (1) summary
    TIGR03182
    Location:61 → 372
    PDH_E1_alph_y; pyruvate dehydrogenase E1 component, alpha subunit

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133180.1 Reference GRCz12tu Primary Assembly

    Range
    24687330..24700742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073950109.1 → XP_073806210.1  pyruvate dehydrogenase E1 subunit alpha 1a isoform X2

  2. XM_005165134.6 → XP_005165191.1  pyruvate dehydrogenase E1 subunit alpha 1a isoform X3

    UniProtKB/TrEMBL
    A0A0R4IT09, A0A8M2BCB9
    Related
    ENSDARP00000139481.1
    Conserved Domains (1) summary
    TIGR03182
    Location:68 → 379
    PDH_E1_alph_y; pyruvate dehydrogenase E1 component, alpha subunit

  3. XM_073950108.1 → XP_073806209.1  pyruvate dehydrogenase E1 subunit alpha 1a isoform X1

  4. XM_073950110.1 → XP_073806211.1  pyruvate dehydrogenase E1 subunit alpha 1a isoform X4

Nucleotide Protein Strain
Heading Accession and Version

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