lgmn legumain [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lgmnprovided by ZNC
Official Full Name: legumainprovided by ZNC
Primary source: ZFIN:ZDB-GENE-021030-1
See related: Ensembl:ENSDARG00000039150 AllianceGenome:ZFIN:ZDB-GENE-021030-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb173; cb460; sb:cb173; zgc:76953; wu:fa98g05; wu:fj92g08
Summary: Predicted to enable cysteine-type endopeptidase activity. Acts upstream of or within several processes, including axon regeneration; negative regulation of bone mineralization; and negative regulation of osteoblast differentiation. Is expressed in several structures, including cardiovascular system; immature eye; mesoderm; nervous system; and pleuroperitoneal region. Orthologous to human LGMN (legumain). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	13	NC_133188.1 (39501807..39512398, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (36039675..36050266, complement)

Chromosome 13 - NC_133188.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fa98g05.x1 (e-PCR)
- UniSTS:202629

fb61a10.y1 (e-PCR)
- UniSTS:190867

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis involved in protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis involved in protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vacuolar protein processing	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: legumain

Names: AEP

NP_999924.1

EC 3.4.22.34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.