spred1 sprouty related EVH1 domain containing 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: spred1provided by ZNC
Official Full Name: sprouty related EVH1 domain containing 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2338
See related: Ensembl:ENSDARG00000041449 AllianceGenome:ZFIN:ZDB-GENE-040426-2338
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb14c08; fj51c03; zgc:85707; wu:fb14c08; wu:fj51c03
Summary: Predicted to enable protein kinase binding activity. Acts upstream of or within blood vessel morphogenesis; lymph vessel development; and regulation of vascular endothelial growth factor receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Legius syndrome. Orthologous to human SPRED1 (sprouty related EVH1 domain containing 1). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	17	NC_133192.1 (58761345..58787163, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (52639492..52658733, complement)

Chromosome 17 - NC_133192.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb14c08.x1 (e-PCR)
- UniSTS:202918

fk88d04.x1 (e-PCR)
- UniSTS:201665

fj51c03.x1 (e-PCR)
- UniSTS:188644

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lymph vessel development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sprouty-related, EVH1 domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213232.1 → NP_998397.1 sprouty-related, EVH1 domain-containing protein 1

See identical proteins and their annotated locations for NP_998397.1

Status: PROVISIONAL

Source sequence(s)

BC068365

UniProtKB/TrEMBL

Q6NV01

Related

ENSDARP00000060763.5, ENSDART00000060764.6

Conserved Domains (2) summary

cd10574
Location:12 → 123

EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain

pfam05210
Location:280 → 378

Sprouty; Sprouty protein (Spry)

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

NC_133192.1 Reference GRCz12tu Primary Assembly

Range

58761345..58787163 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_073927140.1 → XP_073783241.1 sprouty-related, EVH1 domain-containing protein 1 isoform X1
XM_073927139.1 → XP_073783240.1 sprouty-related, EVH1 domain-containing protein 1 isoform X1
XM_073927142.1 → XP_073783243.1 sprouty-related, EVH1 domain-containing protein 1 isoform X1